Name: high speed droplet-based delivery system for passive pumping in microfluidic devices
Uploaded: 2009-09-02T11:00:00
Description: Watch this Scientific Journal Video about High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices at JoVE.com

<p class="jove_content">经费是由美国威斯康星州发现的研究所。 </p>

<p class="jove_content">在这份报告中，我们展示了一个流体输送的方法，利用小液滴表面张力泵通过一个微流体通道所需的量，以达到不同的流体现象。例如，用户可能希望尽可能快流单液，或在连续快速创建特定的流体模式提供多种流体。为了做到这一点，用户必须首先有一个微流体装置周围建立了一个应用程序。 microflluidic设备并不需要保税，但应该从一个亲水性材料。 Therfore，该方法可以利用几乎所有的微流体?...

<ol>
	<li>Berthier, E., Beebe, D. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Flow+rate+analysis+of+a+tension+driven+passive+micropump.">Flow rate analysis of a tension driven passive micropump.</a> <em style='font-style: italic'>Lab Chip</em>. <b>7</b>, 1475-1478 (2007).</li><li>Duffy, D. C., McDonald, J. C., Schueller, O. J. A., Whitesides, G. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Rapid+Prototyping+of+Microfluidic+Systems+in+Poly(dimethylsiloxane).">Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane).</a> <em style='font-style: italic'>Anal. Chem</em>. <b>70</b>, 4974-4984 (1998).</li><li>Harris, J., Lee, H., Vahidi, B., Tu, C., Cribbs, D., Cotman, C., NL, J. e. o. n. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Non-plasma+Bonding+of+PDMS+for+Inexpensive+Fabrication+of+Microfluidic+Devices.">Non-plasma Bonding of PDMS for Inexpensive Fabrication of Microfluidic Devices.</a> <em style='font-style: italic'>J Vis Exp</em>.  (9), (2007).</li><li>Walker, G. M., Beebe, D. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+passive+pumping+method+for+microfluidic+devices.">A passive pumping method for microfluidic devices.</a> <em style='font-style: italic'>Lab Chip</em>. <b>2</b> (3), 131-134 (2002).</li></ol>

<ol><li>对于高速抽水，如果选择正确的组合（由于正确的开放时间）的频率和脉冲量每被动，用户应该看到什么似乎是一个静态的下降或壳入口和通道内的流动速度非常快。如果发生溢出，开放时间和/或频率过高。 </li><li>要检测的势头/表面张力的相互作用，用户应在泵一个脉冲，而脉冲发生（从开始到结束），观察通道内的环境。作者建议使用荧光珠，提供了一个通道内流体行为的准确描述。一个单一入口下降?...

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<td>Sylgard 184 Silicone elastometer base</td>
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high speed droplet-based delivery system for passive pumping in microfluidic devices

<p class="jove_content">一种新型的微流体系统已经开发使用的被动抽水用户控制液滴基于流体输送系统沿现象。被动式抽水，是由表面张力引起的压力差驱动流体运动的现象在封闭的渠道。自动化流体输送系统由电压控制阀，微流体水库和控制系统连接到喷嘴。这些电压的控制阀，提供了一个容积精确的方式提供高频率地在微流体装置的入口流体液滴。在目前的研究例子展示了尺寸的基础上，该系统能够流动每分钟4毫升（通过260um截面渠道2.2毫米）。根据这些相同的通道尺寸，通道内的流体交换可以实现低至8毫秒。据观察，有动力系统（在通道的阀门和流体的速度创造了水滴的组合传授），液体的表面张力之间的相互作用。势头提供了速度，流体的流量（或反之亦然），在入口处的表面张力的平衡提供了任何流量的突然停止。这突然停止，允许用户控制通道的流量特性和各种生物应用打开门，不等药物细胞研究试剂交付。它也观察到，喷嘴的目的是在浅层的角度入口时，液滴的势头可能会造成额外的有趣流体现象，如在多个入口液滴混合，。</p>

Watch this Scientific Journal Video about High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices at JoVE.com

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

<p class="jove_content">一种新型的微流体系统已经开发使用的被动式抽水的现象和用户控制流体输送系统。这种微流体系统已在多种生物应用由于其成本低，易于使用，体积精度高，速度快，重复性和自动化的潜力。</p>

基于液滴在微流体装置的被动抽水高速输送系统

A novel microfluidic system has been developed that uses the phenomenon of passive pumping along with a user controlled droplet based fluid delivery ...

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