Benzodiazepines are a class of anxiolytic drugs known for their rapid efficacy and high therapeutic-to-lethal dose ratio, but with a potential risk of drug dependence. These drugs are lipophilic, allowing for rapid absorption after oral administration, eventually reaching the central nervous system (CNS). Once in the CNS, benzodiazepines bind to the allosteric site of the GABA_A receptor. This binding enhances the inhibitory effects of the neurotransmitter GABA. By doing so, they prevent excessive neurotransmission, helping to alleviate anxiety symptoms effectively.

There are three main types of benzodiazepines, each with varying durations of action. Short-acting benzodiazepines like alprazolam (Xanax) provide quick relief. Intermediate-acting ones, such as lorazepam (Ativan), offer a more extended duration of action. Long-acting benzodiazepines like diazepam (Valium) remain active for 1-3 days.

However, the use of benzodiazepines is associated with common side effects, including drowsiness, confusion, cognitive dysfunction, impaired body coordination, and the potential for drug dependence. These side effects underscore the importance of careful prescribing and monitoring by healthcare professionals. Benzodiazepines are intended for short-term use, to address acute anxiety, in order to avoid dependence or withdrawal symptoms.

In contrast to benzodiazepines, buspirone (Buspar), a partial agonist, binds to 5-HT_1A receptors, promotes serotonin-associated neuronal activity to alleviate anxiety. Its anxiolytic effects manifest gradually, with full effect taking up to 4 weeks. They are particularly effective for treating generalized anxiety disorder. Unlike benzodiazepines, buspirone impairs psychomotor functions less, and is less sedating, than benzodiazepines, and does not cause anti-seizure effects. This makes it a preferred choice for individuals who need anxiety relief without the associated sedation or cognitive impairment.

However, buspirone does have its set of adverse effects. Dizziness, headache and nausea are the most common. Other side effects include chest pain, tachycardia, palpitations, and gastrointestinal distress. While the adverse effects of buspirone are generally less severe than those of benzodiazepines, they highlight the need for careful monitoring and adjustment of dosage based on individual patient responses, ensuring the best possible outcomes in treating anxiety disorders.