The human body employs intricate mechanisms to counteract changes in blood pH, preventing conditions like acidosis (pH < 7.35) and alkalosis (pH > 7.45). These compensatory responses aim to restore normal arterial blood pH by engaging respiratory or renal systems, depending on the source of the imbalance.
Respiratory Compensation
This mechanism addresses metabolic-induced pH imbalances by adjusting breathing rates. Respiratory compensation begins within minutes of detecting a pH disturbance and reaches peak efficacy within hours.
Renal Compensation
The kidneys take over with renal compensation when the pH imbalance originates from respiratory causes. This process involves the kidneys modulating the secretion and reabsorption of H⁺ and bicarbonate ions (HCO3⁻) in the tubules. Although renal responses begin within minutes, they take several days to reach maximum effectiveness.
These compensatory mechanisms highlight the body’s ability to dynamically regulate blood pH, ensuring stability for critical physiological processes. While respiratory compensation is faster, renal compensation provides a more robust and long-term solution to acid-base imbalances.
From Chapter 30:
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