The gastrointestinal elimination process involves a complex interplay of neural and hormonal mechanisms that coordinate the final waste removal from the body. This intricate operation encompasses the absorption of water and electrolytes, vital for transforming the remaining indigestible food matter into feces. The large intestine is pivotal in water and electrolyte absorption, forming feces from unabsorbed minerals, undigested food, bacteria, bile pigments, and shed epithelial cells. Essential to this process, mucus secretion facilitates fecal movement and protects the mucosa.

Key to this process is the activity of the gut microbiota, which not only assists in breaking down substances the body cannot digest but also synthesizes essential vitamins and contributes to the metabolism of bile acids and amino acids, affecting the overall energy balance and health.

Waste movement through the colon is governed by slow, rhythmic contractions that mix the contents, promoting water absorption and stronger waves of peristalsis triggered by reflexes such as the gastrocolic reflex following a meal. These movements culminate in the act of defecation, a carefully coordinated event that involves the relaxation of the internal and voluntary control of the external anal sphincters.

Defecation reflexes are initiated when the rectum is stretched by fecal matter, signaling the need to evacuate. While the internal sphincter relaxes automatically, the external sphincter's relaxation requires conscious effort, aided by abdominal muscle contraction through the Valsalva maneuver. The Valsalva maneuver is a method of consciously increasing the abdominal pressure to assist in defecation but is contraindicated in certain conditions due to potential adverse cardiovascular effects.

This detailed overview reveals the elimination phase as a complex yet efficient process designed to conserve essential nutrients and water while eliminating waste, a testament to the gastrointestinal system's crucial role in maintaining homeostasis and overall health.