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Biolayer Interferometry (BLI) for Evaluating PROTACS-Induced Ternary Complex Formation

166 Views

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01:23 min

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January 12th, 2024

DOI :

10.3791/200655-v

January 12th, 2024

•
166 Views
1Center for the Development of Therapeutics, The Broad Institute of MIT and Harvard

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Biolayer Interferometry
BLI
PROTACS
Ternary Complex Formation
VHL
MZ1
BRD4
Binary Complex
Ternary Complex
On Rate
Off Rate
Equilibrium Dissociation Constant

From the series

Characterization of Ternary Complex Formation in PROTACs Using Biophysical Assays
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