predicting the binding of sdg active components to anus eczema targets

פרמקולוגיה ברשת וניתוח מערך נתונים GEO של SDG בטיפול אקזמה בפי הטבעת

Anal eczema is an allergic skin condition that affects the perianal region and mucosa, exhibiting various clinical manifestations1. The characteristic symptoms include anal erythema, papules, blisters, erosion, exudates, and crusting. These symptoms mostly arise due to scratching, thickening, and roughness of the affected area2.
Anal eczema, characterized by a prolonged duration of the disease, recurrent attacks, and challenging treatment, can have adverse effects on patients&#39; physical and mental health3. The pathogenesis of anal eczema is not yet clear, and modern medicine suggests that it may be related to local anal lesions, diet, environment, genetics, and other factors4. In addition to avoiding contact with irritants and potential allergens, the treatment of anal eczema mainly focuses on methods such as inhibiting inflammation, anti-allergy, and relieving itching5.
SDG has been extensively utilized for the treatment of anal eczema and other anal conditions. SDG regulates anal skin exudation, reduces moisture, repairs anal skin, and effectively addresses pruritus6,7,8. Furthermore, SDG has the potential to regulate perianus microbiota, thereby improving anus eczema9,10.
Network pharmacology, a novel and interdisciplinary, cutting-edge bioinformatic approach in the realm of artificial intelligence and big data, provides an in-depth exploration of traditional Chinese medicine. This discipline emphasizes the systemic expounding of molecular correlation rules between drugs and diseases from an ecological network perspective. It has been extensively adopted for various aspects, including identifying key active ingredients in herb extracts, deciphering their global mechanisms of action, formulating drug combinations, and studying prescription compatibility. Traditional Chinese prescriptions exhibit the attributes of multi-component and multi-target, signifying their substantial adaptability to the realm of network pharmacology. Driven by this methodology, fresh perspectives have emerged in the examination of complex traditional Chinese medicine systems, furnishing robust technical support for clinical application rationalization and drug innovation11,12,13,14.
This study aims to explore the mechanism of effectiveness of SDG in the treatment of anal eczema. This investigative effort sought to elucidate the mechanism of topical drug administration using a synergistic integration of network pharmacology and GEO datasets. The findings provide valuable insights into the efficacy and underlying mechanisms of SDG in the management of anus eczema, indicating its potential as an effective therapeutic approach for this condition.The detailed workflow diagram of the study is presented in Figure 1.

מחבר זרקור: חקר הגישה הרב-תכליתית של ShiDuGao בטיפול אקזמה בפי הטבעת

היעילות ומנגנוני המסלול הבסיסיים של טיפול ShiDuGao לאקזמה בפי הטבעת בהתבסס על מערכי נתונים של GEO ופרמקולוגיה של רשת

חיזוי קשירת רכיבים פעילים של SDG למטרות אקזמה לפי הטבעת

Research

JoVE Journal

Medicine

Predicting the Binding of SDG Active Components to Anus Eczema Targets

The Efficacy and Underlying Pathway Mechanisms of ShiDuGao Treatment for Anus Eczema Based on GEO Datasets and Network Pharmacology

Anus eczema is a chronic and recurrent inflammatory skin disease affecting the area around the anus. While the lesions primarily occur in the anal and ...

Identifying Disease Targets and Active Components in Traditional Chinese Medicine for Anus Eczema

Establishing a Drug-Component-Disease-Target Network, GO and KEGG Enrichment, and GEO Gene Chip Dataset Analysis in Anus Eczema

הקמת רשת יעד לתרופות-רכיבים-מחלות, העשרת GO ו-KEGG, וניתוח מערך נתונים של שבבי גנים GEO באקזמה של פי הטבעת