pre-scan preparation and coaching of subject for 129xe mri of lung ventilation

En standardiseret arbejdsgang til hyperpolariseret 129Xe MR til undersøgelse af lungefunktion

Hyperpolarized 129Xe MRI is an exciting tool for non-invasive, spatially-resolved characterization and quantification of specific aspects of pulmonary function1,2,3. Acquisition and reconstruction approaches similar to those used in anatomical proton MRI yield images of inhaled 129Xe in the lungs, permitting visualization of non-ventilated lung regions and region-resolved quantification of ventilation distribution4,5,6,7,8. More advanced pulse sequence and analysis techniques yield further complementary information, including quantification of gas-exchange efficacy between alveoli and pulmonary capillaries via spectroscopic MRI9,10,11,12,13 and characterization of alveolar microstructure integrity via diffusion-weighted MRI14,15,16.
Inhaled 129Xe has been proven safe and tolerable in adult and pediatric subjects, including those with pulmonary disease17,18. Measurements of lung function derived from 129Xe MRI have shown sensitivity to structural and functional alterations in many pulmonary disease contexts, including chronic obstructive pulmonary disease6,10,19, cystic fibrosis20,21,22, idiopathic pulmonary fibrosis23,24,25, and asthma7,10,26. Given the high safety and tolerability of 129Xe MRI, the lack of ionizing radiation in MRI compared with other common imaging approaches, and the high reproducibility of 129Xe MRI results27,28, 129Xe MRI holds significant promise, in particular for precise serial monitoring of individuals receiving a time course of therapy for chronic pulmonary disease.
The safety and clinical promise of 129Xe MRI have led to its FDA approval in December 2022 for lung ventilation imaging in persons aged 12 years and older29. Given this, it is anticipated that the number of research and clinical sites capable of performing 129Xe MRI (currently ~20 worldwide) will increase significantly over the coming years. As 129Xe MRI spreads to new institutions, it is important that robust methodological resources exist to allow sites to build out clinically relevant 129Xe MRI techniques quickly and to perform scans and generate results that are closely comparable with those of existing sites.
In this work, we will outline the current best practices for human hyperpolarized 129Xe MRI of lung ventilation, as agreed upon by member institutions of the 129Xe MRI Clinical Trials Consortium (Xe MRI CTC) and summarized in a recent position paper30. Topics will include the preparation of tailored pulse sequences ideal for a complete 129Xe MRI workflow, preparation, and administration of hyperpolarized 129Xe gas, an optimized workflow for human 129Xe MRI sessions, and best practices for monitoring subject safety and comfort during MRI sessions.

Forfatter Spotlight: Standardisering og bedste praksis for fremme af lungebilleddannelse ved hjælp af 129Xe MR

Erhvervelse af hyperpolariserede 129Xe magnetiske resonansbilleder af lungeventilation

Our research seeks to establish Xenon MRI as a clinical tool for characterizing lung function. Xenon MRI allows us to directly visualize ventilation defects in patients with obstructive lung diseases like COPD, asthma, and cystic fibrosis. It offers information that can't be obtained from standard MRI and pulmonary function test.Xenon MRI was recently approved by the FDA for clinical evaluation of lung ventilation. This represents a culmination of a huge amount of effort by the people in our field and it's an exciting opportunity to show how Xenon MRI can improve patient care and outcomes in pulmonary disease. Xenon MRI is still a relatively new family of techniques, and standardization is still an ongoing process.This protocol distills the existing standards for Xenon ventilation MRI into a form that we hope will be useful to research in clinical sites who are trying to perform these scans for the first time. Common clinical readouts of lung function, like pulmonary function tests, only give a single number for the entire lung with no spatial information included. Xenon MRI can make regional assessments of several aspects of lung health and function, which we believe will be very useful in the clinic.Only a few institutions are currently performing Xenon MRI, but we expect there will be many more sites soon considering the recent FDA approval. We hope that this Xenon ventilation MRI protocol will serve as a blueprint for new sites and help em to ramp up their Xenon MRI operations more quickly.

Pre-scan forberedelse og coaching af forsøgsperson til 129Xe MR af lungeventilation

Til at begynde med skal du forberede en eller flere Tedlar-poser, der indeholder luft, til emnet til at øve uden for scanneren. Brug en luftmængde, der svarer til den samlede mængde xenon og buffergas, der skal indåndes fra posen under selve undersøgelsen. Forbered næseklemmer, som motivet skal bære under scanning af åndedrættet, monter næseklemmerne på motivets næse, før åndedrættet starter.Brug en luftfyldt taske til hvert forsøg på at coache motivet. Før du producerer posen, skal du bede motivet om at trække vejret ind og ånde ud regelmæssigt flere gange. Under proceduren skal du overvåge motivets bryst for at bekræfte, at de udfører instruktionerne korrekt.Placer derefter røret, der er fastgjort til Tedlar-posen, i motivets mund. Hold posen, så motivet kan indånde fra den og åbne ventilen. Bed motivet om at trække vejret ind, og bed derefter motivet om at holde vejret ved at sige, hold vejret.Når du øver dig, skal du vente på en optælling på 10 til 15 sekunder, hvilket er den omtrentlige tid, der kræves for at en typisk xenon 129-scanning kan forløbe. Bed derefter motivet om at udånde på dette tidspunkt og trække vejret. Coach forsøgspersonen til at tage flere dybe indåndinger ind og ud for en hurtigere clearance af xenon 129 fra lungerne og en hurtigere tilbagevenden til normale iltmætningsniveauer.Kontroller, at forsøgspersonen er i stand til at udføre instruktionerne pålideligt, og overvej at udelukke forsøgspersoner, der ikke kan gøre det under øvelseskørsler.

Research

JoVE Journal

Medicine

Pre-Scan Preparation and Coaching of Subject for 129Xe MRI of Lung Ventilation

Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation

Hyperpolarized 129Xe MRI comprises a unique array of structural and functional lung imaging techniques. Technique standardization across sites is ...

Preparation of MRI Scanner Room and Subject Positioning for 129Xe MRI of Lung Ventilation

Forberedelse af MR-scannerrum og emnepositionering til 129Xe MR af lungeventilation

Performing 129Xe MRI Scan of Lung Ventilation to Assess Pulmonary Function

Udførelse af 129Xe MR-scanning af lungeventilation for at vurdere lungefunktionen