preparation of mri scanner room and subject positioning for 129xe mri of lung ventilation

A Standardized Workflow for Hyperpolarized 129Xe MRI to Study Pulmonary Function

Hyperpolarized 129Xe MRI is an exciting tool for non-invasive, spatially-resolved characterization and quantification of specific aspects of pulmonary function1,2,3. Acquisition and reconstruction approaches similar to those used in anatomical proton MRI yield images of inhaled 129Xe in the lungs, permitting visualization of non-ventilated lung regions and region-resolved quantification of ventilation distribution4,5,6,7,8. More advanced pulse sequence and analysis techniques yield further complementary information, including quantification of gas-exchange efficacy between alveoli and pulmonary capillaries via spectroscopic MRI9,10,11,12,13 and characterization of alveolar microstructure integrity via diffusion-weighted MRI14,15,16.
Inhaled 129Xe has been proven safe and tolerable in adult and pediatric subjects, including those with pulmonary disease17,18. Measurements of lung function derived from 129Xe MRI have shown sensitivity to structural and functional alterations in many pulmonary disease contexts, including chronic obstructive pulmonary disease6,10,19, cystic fibrosis20,21,22, idiopathic pulmonary fibrosis23,24,25, and asthma7,10,26. Given the high safety and tolerability of 129Xe MRI, the lack of ionizing radiation in MRI compared with other common imaging approaches, and the high reproducibility of 129Xe MRI results27,28, 129Xe MRI holds significant promise, in particular for precise serial monitoring of individuals receiving a time course of therapy for chronic pulmonary disease.
The safety and clinical promise of 129Xe MRI have led to its FDA approval in December 2022 for lung ventilation imaging in persons aged 12 years and older29. Given this, it is anticipated that the number of research and clinical sites capable of performing 129Xe MRI (currently ~20 worldwide) will increase significantly over the coming years. As 129Xe MRI spreads to new institutions, it is important that robust methodological resources exist to allow sites to build out clinically relevant 129Xe MRI techniques quickly and to perform scans and generate results that are closely comparable with those of existing sites.
In this work, we will outline the current best practices for human hyperpolarized 129Xe MRI of lung ventilation, as agreed upon by member institutions of the 129Xe MRI Clinical Trials Consortium (Xe MRI CTC) and summarized in a recent position paper30. Topics will include the preparation of tailored pulse sequences ideal for a complete 129Xe MRI workflow, preparation, and administration of hyperpolarized 129Xe gas, an optimized workflow for human 129Xe MRI sessions, and best practices for monitoring subject safety and comfort during MRI sessions.

Author Spotlight: Standardization and Best Practices for Advancing Lung Imaging Using 129Xe MRI

Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation

Our research seeks to establish Xenon MRI as a clinical tool for characterizing lung function. Xenon MRI allows us to directly visualize ventilation defects in patients with obstructive lung diseases like COPD, asthma, and cystic fibrosis. It offers information that can't be obtained from standard MRI and pulmonary function test.Xenon MRI was recently approved by the FDA for clinical evaluation of lung ventilation. This represents a culmination of a huge amount of effort by the people in our field and it's an exciting opportunity to show how Xenon MRI can improve patient care and outcomes in pulmonary disease. Xenon MRI is still a relatively new family of techniques, and standardization is still an ongoing process.This protocol distills the existing standards for Xenon ventilation MRI into a form that we hope will be useful to research in clinical sites who are trying to perform these scans for the first time. Common clinical readouts of lung function, like pulmonary function tests, only give a single number for the entire lung with no spatial information included. Xenon MRI can make regional assessments of several aspects of lung health and function, which we believe will be very useful in the clinic.Only a few institutions are currently performing Xenon MRI, but we expect there will be many more sites soon considering the recent FDA approval. We hope that this Xenon ventilation MRI protocol will serve as a blueprint for new sites and help em to ramp up their Xenon MRI operations more quickly.

Preparation of MRI Scanner Room and Subject Positioning for 129Xe MRI of Lung Ventilation

To begin, ensure anyone entering the MRI scanner room has removed all metallic and electronic objects from their body or pockets. Prepare the Xenon 129 vest coil by plugging it into the scanner and placing it on the MRI scanner patient table. Instruct the subject to lie on the patient table in a feet first or head first supine position depending on the layout of the scanner room.Place pillows under the subject's head, knees, et cetera, as needed to ensure comfort during the procedure. Secure the Xenon 129 vest coil around the subject's chest while keeping the coil midline in the head-foot direction as close as possible to the expected midline of the subject's lungs when the subject is at a comfortable inflation level. Placing the coil to low on the subject may result in undesirable signal reductions at the periphery of the lungs.Set up an MRI safe pulse oximeter next to the patient table in the MRI scanner room and connect the pulse oximeter probe to the subject. Verify that the pulse oximeter is reading correctly. Place a nasal cannula in the subject's nose and connect it to an oxygen source to be used after dose inhalation if needed.Place the oxygen tank and regulator in an MRI safe manner based on local safety policy within reachable distance. Advance the patient table into the MRI scanner, aligning the midline of the coil or the subject's lungs to the scanner's isocenter. The images shown here represent the ventilation images from a study that was unknowingly performed using a Xenon 129 vest coil with a damaged cable.The right lung displays a lower signal-to-noise ratio than the left lung. The ventilation images from a study that was performed with the Xenon 129 vest coil placed too far toward the subject's feet are shown here. Artificially low Xenon 129 signal is observed in both lung apices due to the lack of receiver sensitivity there.