ultrasound scanning of the submandibular gland for examining sjogren&#39;s syndrome

Techniek voor speekselklier echografisch onderzoek van het syndroom van Sjögren

Sjogren's syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration in exocrine glands, including the salivary and lacrimal glands. Xerostomia, keratoconjunctivitis sicca, and extraglandular manifestations, including arthralgia, cytopenia, and lymphoma, are described in patients with SS. SS can be divided into primary and secondary types, in which the latter occurs in association with other connective tissue diseases. In the 2016 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for primary SS, anti-SSA/Ro positivity and lymphocytic infiltration in labial salivary gland biopsy contributed to the two major criteria, whereas Schirmer's test, ocular staining score, and unstimulated salivary flow represented the rest of the minor criteria1. The criteria are summarized in Table 1. Labial biopsy is an invasive procedure with potential complications, including sampling error, sensory loss, and hematoma formation2. Ocular staining tests and salivary flow assessment require specialized settings and might not be widely available. 
Salivary gland ultrasonography (SGUS) is a non-invasive imaging modality that provides a detailed examination of the superficial salivary gland structure, which is commonly affected in patients with SS. Lymphocytic infiltration and inflammation in the salivary glands often lead to fatty infiltration, fibrosis, and loss of parenchyma, resulting in parenchymal inhomogeneity detected in SGUS3. The Outcome Measures in Rheumatology Clinical Trials (OMERACT) working group derived an ultrasound scoring system from grades 0 to 3 to semi-quantify inhomogeneity and the presence of hypoechoic areas within the parotid or submandibular glands4. A cutoff of grade 2 or above in at least one gland was found to correlate with positive labial biopsies, sialometry, and positive autoantibodies5. It demonstrated excellent specificity and good sensitivity in fulfilling the 2016 ACR/EULAR classification criteria for primary SS when given similar weight as the minor criteria. This protocol presents a standardized and practical approach for diagnosing SGUS in SS in clinical settings.

Auteur in de schijnwerpers: een focus op het gestandaardiseerde echografieprotocol voor speekselklieren in onderzoek naar bindweefselziekten

Echografie van speekselklieren voor het syndroom van Sjögren: diagnostische en monitoringinzichten

Our research focus is connective tissue diseases, including Sjogren's syndrome, and we will describe a standardized approach to saliva and ultrasound in diagnosing Sjogren's syndrome. We hope the protocol will be useful for clinicians unfamiliar with doing ultrasound to enhance its application in clinical practice. Ultrasound is a powerful tool in evaluating various rheumatological conditions, including arthritis, sjogren syndrome, and interstitial lung disease.It is helpful in diagnosis, monitoring and prognostication. It can be applied as an outcome measure in clinical studies such as detecting subclinical synovitis to assess the risk of rheumatoid arthritis progression. Ultrasound is an operator-dependent procedure and the result may be unreliable if inexperienced, hence performed.Well validated and quantitative measurements are often needed to standardize the description and reporting of pathological sonographic findings before they can be applied in clinical practice and research. In this procedure, we will describe how to conduct a salivary gland ultrasound in patients with sicker symptoms. This approach is easy to perform and can usually be completed within 10 to 15 minutes.We'll also demonstrate techniques to perform reliable and reproducible results to ensure the quality of the ultrasound scanning. Our center will continue to research on applying ultrasound in diagnosis and monitoring in rheumatology. We will research utilizing lung ultrasound for screening of interstitial lung disease associated with connective tissue diseases, hoping to improve the current screening strategy for lung fibrosis in rheumatology patients.

Echografie van de submandibulaire klier voor het onderzoeken van het syndroom van Sjögren

Plaats de patiënt in rugligging met het hoofd maximaal naar achteren gekanteld. Om het transversale zicht van de submandibulaire klier te verkrijgen, plaatst u de transducer net onder de hoek van de onderkaak in het submandibulaire gebied. Onderzoek de gehele submandibulaire klier van voorste naar achterste, de onderkaak, mylohyoïde spieren en de voorste buik van de maagspieren bonden deze vast.Verkrijg het longitudinale zicht door de sonde mediaal ten opzichte van het horizontale lichaam van de onderkaak te plaatsen. Visualiseer de gezichtsslagader in dit vlak. Sla de afbeeldingen op en label ze in zowel transversale als longitudinale aanzichten van de submandibulaire klier.Beoordeel de grootte van de submandibulaire klier. Onderzoek de echogeniciteit van de submandibulaire klier, die meestal minder echogeen is dan de oorspeekselklier. Beoordeel de mate van inhomogeniteit, de helderheid van de klierrand en de aanwezigheid van hypo- of an-echoïsche gebieden in de klieren.Let op de aanwezigheid van focale laesies. Beoordeel de mate van inhomogeniteit met behulp van de OMERACT-score. Als de evaluatie van de klier niet mogelijk is vanwege kwalitatieve parameters, volg dan de alternatieve beoordelingsparameters.Meet de grootte van de submandibulaire lymfeklieren, evalueer vette hilums, vorm, echogeniciteit en behoud. Herhaal het scannen bij de contralaterale submandibulaire klier en vergelijk de grootte en echotextuur tussen de twee submandibulaire klieren. Normale submandibulaire klieren vertoonden een duidelijke afbakening met de bovenliggende structuren.

Research

JoVE Journal

Medicine

Ultrasound Scanning of the Submandibular Gland for Examining Sjogren&#39;s Syndrome

Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights

Sjogren's syndrome (SS) is a chronic autoimmune condition commonly affecting the exocrine glands, causing oral or ocular dryness and extraglandular ...

Ultrasound Setting and Scanning of the Thyroid Gland for Examining Sjogren&#39;s Syndrome

Echografie instelling en scannen van de schildklier voor het onderzoeken van het syndroom van Sjögren

Ultrasound Scanning of the Parotid Gland for Examining Sjogren&#39;s Syndrome

Echografie van de parotis voor het onderzoeken van het syndroom van Sjögren