Name: investigating the neural mechanisms of aware and unaware fear memory with fmri
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Поддержка, оказываемая Университета Алабамы в Бирмингеме факультета Программа развития Грант.

1. Психофизиология , Biopac Systems, Inc физиологические системы мониторинга (см. табл специального оборудования) не является стандартным оборудованием в большинстве объектов изображения. График 15-30 минут до прибытия участника установить физиологические мониторинга и другого о?...

     

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Методология страх кондиционирования описано здесь служит средством для исследования нейронных механизмов знают и не знают страха процессов памяти. Этот метод использует преимущества одновременного мониторинга поведенческих, вегетативных и МРТ данных. Мониторинг поведенческих (нап...

<table border="1"><tbody><tr><td> Оборудование </td><td> Компания </td><td> Пункт номер </td></tr><tr><td> Комплексная функциональная система Imaging (МФУ-SA) </td><td> Invivo корпорации, Орландо, Флорида </td><td></td></tr><tr><td> Master Control Unit (находится в диспетчерской) Интерфейс периферийного оборудования (находится в камере МРТ) Audio / Visual Display Unit (находится в камере МРТ), включает в себя: <ul><li> 6,4 &quot;(по диагонали) ЖК-экран видео <ul><li> 640 х 480 пикселей и 15 ° поле зрения </li></ul></li><li> акустического окна интерфейса <ul><li> обеспечивает пневматическая звук в режиме стерео </li></ul></li><li> MR-совместимыми стерео наушники </li></ul></td><td></td><td></td></tr><tr><td> Физиологическая система мониторинга </td><td> Biopac Systems, Inc, Goleta </td><td></td></tr><tr><td> Данные Acquisitиона и системного анализа для Windows (MP150) Isolated Digital Interface (цифровой интерфейс) Гальваническая кожных реакций (GSR) Усилитель МРТ Кабельное / Filter System для преобразователей набор усилителей, включает в себя: <ul><li> МРТ кабель-удлинитель (палаты для фильтрации) </li><li> Фильтр радиопомех </li><li> МРТ кабель-удлинитель (GSR усилителя для фильтрации) </li></ul> Дополнительные компоненты: DB25 M / F ленточный кабель Одноразовые электроды radiotranslucent Углеродные волокна приводит </td><td></td><td valign="top"> MP150WSW STP100C EDA100C-МРТ MECMRI-TRANS - MECMRI-1 - MRIRFIF - MECMRI-3 CBL110C EL508 LEAD108 </td></tr><tr><td> ДЖОЙСТИК </td><td> Данной Designs, Inc, Philadelphia, PA </td><td></td></tr><tr><td> Наследие Джойстик </td><td></td><td> HH-JOY-4 </td></tr><tr><td> Наследие при р интерфейса </td><td></td><td> ПФР-005 </td></tr></tbody></table>

investigating the neural mechanisms of aware and unaware fear memory with fmri

Pavlovian fear conditioning is often used in combination with functional magnetic resonance imaging (fMRI) in humans to investigate the neural substrates of associative learning 1-5. In these studies, it is important to provide behavioral evidence of conditioning to verify that differences in brain activity are learning-related and correlated with human behavior. 
Fear conditioning studies often monitor autonomic responses (e.g. skin conductance response; SCR) as an index of learning and memory 6-8. In addition, other behavioral measures can provide valuable information about the learning process and/or other cognitive functions that influence conditioning. For example, the impact unconditioned stimulus (UCS) expectancies have on the expression of the conditioned response (CR) and unconditioned response (UCR) has been a topic of interest in several recent studies 9-14. SCR and UCS expectancy measures have recently been used in conjunction with fMRI to investigate the neural substrates of aware and unaware fear learning and memory processes 15. Although these cognitive processes can be evaluated to some degree following the conditioning session, post-conditioning assessments cannot measure expectations on a trial-to-trial basis and are susceptible to interference and forgetting, as well as other factors that may distort results 16,17 .
Monitoring autonomic and behavioral responses simultaneously with fMRI provides a mechanism by which the neural substrates that mediate complex relationships between cognitive processes and behavioral/autonomic responses can be assessed. However, monitoring autonomic and behavioral responses in the MRI environment poses a number of practical problems. Specifically, 1) standard behavioral and physiological monitoring equipment is constructed of ferrous material that cannot be safely used near the MRI scanner, 2) when this equipment is placed outside of the MRI scanning chamber, the cables projecting to the subject can carry RF noise that produces artifacts in brain images, 3) artifacts can be produced within the skin conductance signal by switching gradients during scanning, 4) the fMRI signal produced by the motor demands of behavioral responses may need to be distinguished from activity related to the cognitive processes of interest. Each of these issues can be resolved with modifications to the setup of physiological monitoring equipment and additional data analysis procedures. Here we present a methodology to simultaneously monitor autonomic and behavioral responses during fMRI, and demonstrate the use of these methods to investigate aware and unaware memory processes during fear conditioning.

Watch this Scientific Journal Video about Investigating the Neural Mechanisms of Aware and Unaware Fear Memory with fMRI at JoVE.com

Investigating the Neural Mechanisms of Aware and Unaware Fear Memory with fMRI

Методология для исследования нервных механизмов, которые поддерживают знают и не знают процессов памяти во время страха кондиционирования описано. Этот метод отслеживает уровень кислорода в крови зависимые (BOLD) функциональной магнитно-резонансной томографии, ответ проводимости кожи, и безусловных продолжительность стимула во время павловской кондиционирования страха для оценки нейронных коррелятов различных процессов памяти.

Исследование нейронных механизмов сознавая и не зная страха памяти с МРТ

Pavlovian fear conditioning is often used in combination with functional magnetic resonance imaging (fMRI) in humans to investigate the neural substrates ...

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