Immunohistokemisk farvning af B7-H1 (PD-L1) på paraffinindlejret lysbilleder af adenocarcinom i pancreas Tissue
January 3rd, 2013
•Elaine Bigelow1,2, Katherine M. Bever1,2, Haiying Xu1,2,3, Allison Yager1, Annie Wu1,2,4, Janis Taube3,5, Lieping Chen6, Elizabeth M. Jaffee1,2,5,7,8, Robert A. Anders1,2,5,8, Lei Zheng1,2,4,5,7
1The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 2Department of Oncology, The Johns Hopkins University School of Medicine, 3Department of Dermatology, The Johns Hopkins University School of Medicine, 4Department of Surgery, Johns Hopkins University School of Medicine, 5The Sol Goldman Pancreatic Cancer Center, The Johns Hopkins University School of Medicine, 6Yale Cancer Center, Yale School of Medicine, 7The Skip Viragh Center for Pancreatic Cancer, The Johns Hopkins University School of Medicine, 8Department of Pathology, The Johns Hopkins University School of Medicine
B7-H1 (PD-L1) og dens binding til PD-1 udgør en væsentlig tumorinduceret immunosuppressive signal i tumorens mikromiljø. En immunohistokemisk farvning teknik til karakterisering af ekspression og lokalisering af B7-H1 i pancreas adenocarcinom er beskrevet her.
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