Immunhistokemisk färgning av B7-H1 (PD-L1) på Paraffininbäddade Bilder av Pancreatic Adenocarcinom Tissue
January 3rd, 2013
•Elaine Bigelow1,2, Katherine M. Bever1,2, Haiying Xu1,2,3, Allison Yager1, Annie Wu1,2,4, Janis Taube3,5, Lieping Chen6, Elizabeth M. Jaffee1,2,5,7,8, Robert A. Anders1,2,5,8, Lei Zheng1,2,4,5,7
1The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 2Department of Oncology, The Johns Hopkins University School of Medicine, 3Department of Dermatology, The Johns Hopkins University School of Medicine, 4Department of Surgery, Johns Hopkins University School of Medicine, 5The Sol Goldman Pancreatic Cancer Center, The Johns Hopkins University School of Medicine, 6Yale Cancer Center, Yale School of Medicine, 7The Skip Viragh Center for Pancreatic Cancer, The Johns Hopkins University School of Medicine, 8Department of Pathology, The Johns Hopkins University School of Medicine
B7-H1 (PD-L1) och dess bindning till PD-1 tillhandahåller en stor tumör-inducerad immunosuppressiv signal i tumörens mikromiljö. En immunohistokemisk färgning teknik för att karakterisera uttryck och lokalisering av B7-H1 i pankreatiskt adenokarcinom beskrivs här.
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