Name: mapping cortical dynamics using simultaneous meg/eeg and anatomically-constrained minimum-norm estimates: an auditory attention example
Uploaded: 2012-10-24T13:00:00
Description: Watch this Scientific Journal Video about Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example at JoVE.com

作者要感谢马蒂·S.海迈莱伊宁，Zöllei里拉和审稿人的宝贵意见。资金来源：R00DC010196（AKCL）; T32DC000018（EDL）; T32DC005361（RKM）。

1。解剖数​​据采集与处理<ol><li>收购磁化准备快速梯度回波（MPRAGE）MRI扫描的主题。这可能需要5-10分钟，这取决于使用特定扫描协议。 </li><li>如果EEG数据用于逆成像分析，FLASH序列提供不同的组织从的标准MPRAGE序列1的对比度，获得两个额外的快速低角度拍摄（FLASH）MRI扫描（翻转角= 5°〜30°）。 </li><li> （见表）使用FreeSurfer软件2，3，重建皮质表面，并成立单独的M /脑电偶极...

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为了估计偶极子从收购MEG / EEG数据上皮层的激活，我们需要解决的一个反问题，没有唯一稳定的解决方案，除非适当的解剖和生理健全的约束应用于。使用的解剖收购个别科目使用MRI和采用的最低标准作为我们的估计准则的约束，我们可以得出逆皮层电流源的估计，同意传感器的测量。这种方法已被证明是有用的研究，不仅听觉处理14，但也有其他领域，如视觉15和语言处理16?...

<table border="1"><tbody><tr><td> 设备/软件名称 </td><td> 公司/源 </td><td></td><td></td></tr><tr><td> 306通道Vectorview MEG系统</td><td> Eleka Neuromag有限公司， </td><td></td><td></td></tr><tr><td> 1.5-T的Avanto MRI扫描仪</td><td>西门子医疗解决方案</td><td></td><td></td></tr><tr><td> FreeSurfer </td><td></td><td></td><td> <a href="http://freesurfer.net/" target="_blank">http://freesurfer.net/</a> </td></tr><tr><td>跨国公司软件</td><td></td><td></td><td> <a href="http://www.nmr.mgh.harvard.edu/martinos/userInfo/data/sofMNE.php" target="_blank">http://www.nmr.mgh.harvard.edu/martinos/userInfo/data/sofMNE.php</a> </td></tr><tr><td>脑电图电极</td><td>脑，采集卡有限公司</td><td></td><td></td></tr><tr><td> 3SPACE的FasTrak系统</td><td> Polhemus公司</td><td></td><td></td></tr><tr><td>光按钮盒（FIU-932） </td><td>目前的设计</td><td></td><td></td></tr></tbody></table>

mapping cortical dynamics using simultaneous meg/eeg and anatomically-constrained minimum-norm estimates: an auditory attention example

磁和脑电图（MEG / EEG）的神经影像学技术，提供高时间分辨率，特别适合动态感知和认知能力的任务，如参加一个鸡尾酒会不同的声音在参与调查的皮质神经元网络。许多过去的研究只采用的传感器记录的数据， 即 ，记录外，在头皮上的磁场或电势，并通常集中在活动时间锁定的刺激呈现。这种类型的事件相关领域的/潜在的分析是非常有用的，只有少数不同的偶极模式，可以在时间和空间的分离和鉴定。另外，通过利用解剖信息，这些不同领域的模式可以被本地化为电流源上皮层。然而，对于一个更持久的反应，可能没有时间锁定到一个特定的刺激（ 如 ，准备听之一的两个同时出现的口语线索的听觉特性的基础上的数字），或者可以被分布在多个空间位置未知的先验 ，招募的一个分布式皮质网络可能不会被充分地通过使用有限数量的捕获焦点来源。 在这里，我们描述一个过程，采用个别解剖MRI数据建立的传感器信息和偶极子上皮层的激活，通过使用最小模估计（MNE）之间的关系。这种逆成像方法为我们提供了分布式信源分析工具。为了便于说明，我们将介绍使用FreeSurfer和跨国公司的软件，不管是免费的所有程序。我们将总结MRI序列和分析所需的步骤，以产生正向模型，使我们能够与预期的场模式到M / EEG传感器所造成的偶极子分布在皮层。 NEXT，我们会加强有利于我们在去噪的环境和生理污染物的传感器数据，通过必要的程序。然后，我们将概述的程序，用于组合和的MEG / EEG传感器数据映射到皮层的空间，从而产生皮质偶极激活在脑表面（或“大脑电影”）有关的每个实验条件下的时间序列的家庭。最后，我们将重点介绍一些统计技术，使我们能够在一个受人口（ 即 ，执行组级别分析）基于一个共同的皮质坐标空间科学推断。

Watch this Scientific Journal Video about Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example at JoVE.com

Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example

我们使用磁和脑电图（MEG / EEG），磁共振成像（MRI）拍摄的解剖信息相结合，与听觉注意力的皮质网络的动态映射。

同时MEG / EEG和解剖约束的最小模估计皮质动态映射：听觉注意示例

Magneto- and electroencephalography (MEG/EEG) are neuroimaging techniques that provide a high temporal resolution particularly suitable to investigate the ...

Research

JoVE Journal

Neuroscience

Functional Mapping with Simultaneous MEG and EEG

同时脑磁图和脑电图的功能映射

We use magnetoencephalography (MEG) and electroencephalography (EEG) to locate and determine the temporal evolution in brain areas involved in the ...

科研

神经科学

Preparation and Culture of Chicken Auditory Brainstem Slices

鸡脑干切片的制备及文化

The chicken auditory brainstem is a well-established model system that has been widely used to study the anatomy and physiology of auditory processing at ...

Recording Human Electrocorticographic (ECoG) Signals for Neuroscientific Research and Real-time Functional Cortical Mapping

Recording Human Electrocorticographic ECoG Signals for Neuroscientific Research and Real-time Functional Cortical Mapping

神经科学的研究和实时功能皮层映射记录人力Electrocorticographic（ECOG）信号

Neuroimaging studies of human cognitive, sensory, and motor processes are usually based on noninvasive techniques such as electroencephalography (EEG), ...

Functional Imaging of Auditory Cortex in Adult Cats using High-field fMRI

听觉皮层在成年猫用高场磁共振成像功能成像

Current knowledge of sensory processing in the mammalian auditory system is mainly derived from electrophysiological studies in a variety of animal ...

Optogenetic Stimulation of the Auditory Nerve

听觉神经的光遗传学刺激

Direct electrical stimulation of spiral ganglion neurons (SGNs) by cochlear implants (CIs) enables open speech comprehension in the majority of implanted ...

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond

实时电：采用闭环协议来探测神经动力学和超越

Experimental neuroscience is witnessing an increased interest in the development and application of novel and often complex, closed-loop protocols, where ...

Touchscreen Sustained Attention Task (SAT) for Rats

Touchscreen Sustained Attention Task SAT for Rats

触摸屏持续注意任务 (SAT) 大鼠

Sustained attention is the ability to monitor intermittent and unpredictable events over a prolonged period of time. This attentional process subserves ...

Simultaneous Recordings of Cortical Local Field Potentials, Electrocardiogram, Electromyogram, and Breathing Rhythm from a Freely Moving Rat

自由运动大鼠皮质局部电位、心电图、肌电图和呼吸节律的同步记录

Monitoring the physiological dynamics of the brain and peripheral tissues is necessary for addressing a number of questions about how the brain controls ...

Visualization of Motor Axon Navigation and Quantification of Axon Arborization In Mouse Embryos Using Light Sheet Fluorescence Microscopy

用光片荧光显微镜观察运动轴突导航和小鼠胚轴突树枝状的定量化

Spinal motor neurons (MNs) extend their axons to communicate with their innervating targets, thereby controlling movement and complex tasks in ...

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

由亲炎细胞因子的内脑注射诱导的广度脑皮质脱叶的鼠模型

Multiple sclerosis (MS) is the most common immune-mediated disease of the central nervous system (CNS) and progressively leads to physical disability and ...