Name: mapping cortical dynamics using simultaneous meg/eeg and anatomically-constrained minimum-norm estimates: an auditory attention example
Uploaded: 2012-10-24T13:00:00
Description: Watch this Scientific Journal Video about Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example at JoVE.com

Forfatterne vil gerne takke Matti S. Hämäläinen, Lilla Zöllei og tre anonyme korrekturlæsere for deres nyttige kommentarer. Finansieringskilder: R00DC010196 (AKCL), T32DC000018 (EDL), T32DC005361 (RKM).

1. Anatomisk Data Acquisition and Processing <ol><li> Erhverve en magnetisering forberedt hurtig gradient ekko (MPRAGE) MR-scanning af emnet. Dette kan tage 5-10 min afhængig af hvilken specifik scanning protokol der anvendes. </li><li> Erhverve yderligere to hurtige lav vinkel shot (FLASH) MR-scanninger (flip vinkler = 5 ° og 30 °), hvis EEG data anvendes til inverse billeddannelse analyse, som flash-sekvenser giver forskellige væv kontrast fra standard MPRAGE sekvenserne 1. </li><li> Brug FreeSurfer s...

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For at vurdere den dipole aktivering på cortex fra de tilkøbte MEG / EEG data, er vi nødt til at løse en invers problem, som ikke har en unik stabil løsning, medmindre passende anatomisk og fysiologisk sunde begrænsninger anvendes. Brug af anatomiske begrænsning erhvervet for de enkelte fag ved hjælp af MRI og vedtagelse af minimum-norm som vores skøn kriterium, kan vi nå frem til en invers kortikale aktuelle kilde estimat, der er enig med sensormålinger. Denne fremgangsmåde har vist sig nyttigt i studier af...

<table border="1"><tbody><tr><td> Navn på udstyr / software </td><td> Firma / kilde </td><td></td><td></td></tr><tr><td> 306-kanals Vectorview MEG-system </td><td> Eleka-Neuromag Ltd, </td><td></td><td></td></tr><tr><td> 1,5-T Avanto MRI-scanner </td><td> Siemens Medical Solutions </td><td></td><td></td></tr><tr><td> FreeSurfer </td><td></td><td></td><td> <a href="http://freesurfer.net/" target="_blank">http://freesurfer.net/</a> </td></tr><tr><td> MNE software </td><td></td><td></td><td> <a href="http://www.nmr.mgh.harvard.edu/martinos/userInfo/data/sofMNE.php" target="_blank">http://www.nmr.mgh.harvard.edu/martinos/userInfo/data/sofMNE.php</a> </td></tr><tr><td> EEG elektroder </td><td> Brain Products, Easycap GmbH </td><td></td><td></td></tr><tr><td> 3Space Fastrak-system </td><td> Polhemus </td><td></td><td></td></tr><tr><td> Optisk knap boks (FIU-932) </td><td> Aktuelle Designs </td><td></td><td></td></tr></tbody></table>

mapping cortical dynamics using simultaneous meg/eeg and anatomically-constrained minimum-norm estimates: an auditory attention example

Magneto-og elektroencefalografi (MEG / EEG) er Neuroimaging teknikker, der giver en høj tidsopløsning særligt egnet til at undersøge de kortikale netværk, der er involveret i dynamiske perceptuelle og kognitive opgaver, såsom at deltage i forskellige lyde i et cocktailparty. Mange tidligere undersøgelser har ansat data, der registreres på sensoren niveau kun har dvs., De magnetiske felter eller de elektriske potentialer optaget uden for og på hovedbunden, og som regel fokuseret på aktivitet, der er tid-låst til stimulus præsentation. Denne type begivenhed-relateret område / potentielle analyse er især nyttig, når der kun er et lille antal forskellige dipolære mønstre, der kan isoleres og identificeres i rum og tid. Alternativt ved at anvende anatomiske oplysninger, kan disse forskellige felt mønstre lokaliseres som nuværende kilder på cortex. Men for en mere vedvarende respons som måske ikke er tid-låst til en specifik påvirkning (f.eks.,som forberedelse til at lytte til en af de to samtidigt præsenteret talte cifre baseret på cued auditive funktionen) eller kan være fordelt over flere rumlige placeringer ukendt på forhånd, kan ansætte en fordelt cortical netværk ikke i tilstrækkelig grad fanges ved hjælp af et begrænset antal fokale kilder. Her beskriver vi en fremgangsmåde, der anvender individuelle anatomiske MRI-data til at skabe en forbindelse mellem sensoren information og dipolen aktivering på cortex ved anvendelse af minimum-norm estimater (MNE). Denne omvendte billedbehandling tilgang giver os et redskab til distribueret kilde analyse. Til illustrative formål vil vi beskrive alle procedurer ved hjælp FreeSurfer og MNE software, både frit tilgængelige. Vi vil opsummere MRI sekvenser og analyser nødvendige skridt til at producere en fremadrettet model, der gør os i stand til at relatere det forventede feltmønster forårsaget af dipoler fordelt på cortex på M / EEG sensorer. Next, vil vi gå gennem de nødvendige processer, der letter os i denoising sensordataene fra miljømæssige og fysiologiske stoffer. Vi vil herefter beskrive en metode til at kombinere og kortlægning MEG / EEG sensordata på den kortikale rum, hvorved der dannes en familie af tidsserier af cortical dipol aktivering på hjernen overflade (eller &quot;hjerne-film&quot;) i forbindelse med hver eksperimentel betingelse. Endelig vil vi fremhæve nogle statistiske teknikker, der gør os i stand til at gøre videnskabelig inferens tværs et emne befolkning (dvs.., Udføre gruppe-niveau analyse) baseret på en fælles cortical koordinat rum.

Watch this Scientific Journal Video about Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example at JoVE.com

Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example

Vi bruger magneto-og elektroencefalografi (MEG / EEG), kombineret med anatomiske oplysninger fanget af magnetisk resonans imaging (MRI), at kortlægge dynamikken i den kortikale netværk forbundet med auditive opmærksomhed.

Kortlægning Corticale Dynamics Brug Samtidige MEG / EEG og Anatomisk-begrænset Minimum-norm skøn: en auditiv Attention Eksempel

Magneto- and electroencephalography (MEG/EEG) are neuroimaging techniques that provide a high temporal resolution particularly suitable to investigate the ...

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