Name: minimal erythema dose (med) testing
Uploaded: 2013-05-28T12:00:00
Description: Watch this Scientific Journal Video about Minimal Erythema Dose MED Testing at JoVE.com

Dette arbejde blev finansieret af R21CA134819 (CH), T32CA009035 (SD), og P30CA006927 (Cancer Center Core Grant). Forfatterne vil gerne takke Elizabeth Culnan for hendes hjælp med deltageren rekruttering, Lia Boyle, Eva Panigrahi og Kate Menezes for deres assistance i udvikling af procedurer, og Jeanne Pomenti med sin hjælp med manuskriptet forberedelse. Vi takker også tidsskriftet korrekturlæsere for deres nyttige forslag.

1.. Forberedelse til UV-eksponering <ol><li> Forklar deltageren hvordan MED test værker (&quot;Jeg har tænkt mig at afsløre nogle hud på armen for at UV-lys i løbet af ca 20 min, og i morgen, vi kommer til at kontrollere, at afsnit af din hud for at bestemme hvor følsom du er til lyset. Du kan opleve en solskoldning i de små områder, som vi udsættes for UV. Hvis solskoldning er smertefulde eller generer dig, kan du behandle det som du ville enhver anden solskoldning. &quot;) </li><li> Personale og deltager b?...

<ol>
	<li>Fitzpatrick, T. B. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+validity+and+practicality+of+sun-reactive+skin+types+I+through+VI.">The validity and practicality of sun-reactive skin types I through VI.</a> Archives of Dermatology. 124, 869-871 (1988).</li><li>Bodekaer, M., Akerstrom, U., Wulf, H. C. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Accumulation+of+sunscreen+in+human+skin+after+daily+applications:+a+study+of+sunscreens+with+different+ultraviolet+radiation+filters.">Accumulation of sunscreen in human skin after daily applications: a study of sunscreens with different ultraviolet radiation filters.</a> Photodermatol. Photoimmunol. Photomed. 28, 127-132 (2012).</li><li>Kwon, I. H., Kwon, H. H., Na, S. J., Youn, J. I. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Could+colorimetric+method+replace+the+individual+minimal+erythemal+dose+(MED)+measurements+in+determining+the+initial+dose+of+narrow-band+UVB+treatment+for+psoriasis+patients+with+skin+phototype+III-V?.">Could colorimetric method replace the individual minimal erythemal dose (MED) measurements in determining the initial dose of narrow-band UVB treatment for psoriasis patients with skin phototype III-V?.</a> J. Eur. Acad. Dermatol. Venereol. , (2012).</li><li>Youn, J. I., Park, J. Y., Jo, S. J., Rim, J. H., Choe, Y. B. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Assessment+of+the+usefulness+of+skin+phototype+and+skin+color+as+the+parameter+of+cutaneous+narrow+band+UVB+sensitivity+in+psoriasis+patients.">Assessment of the usefulness of skin phototype and skin color as the parameter of cutaneous narrow band UVB sensitivity in psoriasis patients.</a> Photodermatol. Photoimmunol. Photomed. 19, 261-264 (2003).</li><li>Henriksen, M., Na, R., Agren, M. S., Wulf, H. C. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Minimal+erythema+dose+after+multiple+UV+exposures+depends+on+pre-exposure+skin+pigmentation.">Minimal erythema dose after multiple UV exposures depends on pre-exposure skin pigmentation.</a> Photodermatol. Photoimmunol. Photomed. 20, 163-169 (2004).</li><li>Kraemer, C. K., Menegon, D. B., Cestari, T. F. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Determination+of+the+minimal+phototoxic+dose+and+colorimetry+in+psoralen+plus+ultraviolet+A+radiation+therapy.">Determination of the minimal phototoxic dose and colorimetry in psoralen plus ultraviolet A radiation therapy.</a> Photodermatol. Photoimmunol. Photomed. 21, 242-248 (2005).</li><li>Sachdeva, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Fitzpatrick+skin+typing:+applications+in+dermatology.">Fitzpatrick skin typing: applications in dermatology.</a> Indian J. Dermatol. Venereol. Leprol. 75, 93-96 (2009).</li><li>Webb, A. R., Kift, R., Berry, J. L., Rhodes, L. E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+vitamin+D+debate:+translating+controlled+experiments+into+reality+for+human+sun+exposure+times.">The vitamin D debate: translating controlled experiments into reality for human sun exposure times.</a> Photochem. Photobiol. 87, 741-745 (2011).</li><li>Otman, S. G., Edwards, C., Gambles, B., Anstey, A. V. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Validation+of+a+semiautomated+method+of+minimal+erythema+dose+testing+for+narrowband+ultraviolet+B+phototherapy.">Validation of a semiautomated method of minimal erythema dose testing for narrowband ultraviolet B phototherapy.</a> Br. J. Dermatol. 155, 416-421 (2006).</li><li>Taylor, D. K., Anstey, A. V., Coleman, A. J., Diffey, B. L., Farr, P. M., Ferguson, S., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Guidelines+for+dosimetry+and+calibration+in+ultraviolet+radiation+therapy:+a+report+of+a+British+Photodermatology+Group+workshop.">Guidelines for dosimetry and calibration in ultraviolet radiation therapy: a report of a British Photodermatology Group workshop.</a> Br. J. Dermatol. 146, 755-763 (2002).</li></ol>

Ultraviolet stråling (UV) terapi er undertiden bruges som en behandling for forskellige almindelige hudsygdomme, herunder psoriasis, acne og eksem. Doseringen af UV-lys er foreskrevet i henhold til en persons følsomhed i huden, der bestemmes som en funktion af individets Fitzpatrick hudtype I-VI (meget retfærdig meget mørke). 2 Menneskelig hud varierer i sin følsomhed over for UV-stråling på grund af varierende grader af hudens pigmentering, tykkelse og andre faktorer. Således at etablere den korrekte...

minimal erythema dose (med) testing

Ultraviolet stråling (UV) terapi er undertiden bruges som en behandling for forskellige almindelige hudsygdomme, herunder psoriasis, acne og eksem. Doseringen af ​​UV-lys er foreskrevet i henhold til et individs hud følsomhed. Således at etablere den korrekte dosis af UV lys til at administrere til en patient, er patienten undertiden screenet for at bestemme en minimal erythema dosis (MED), som er den mængde UV-stråling, der vil producere minimal erytem (solskoldning eller rødme forårsaget af overfyldning af kapillærer) af en persons hud inden for et par timer efter eksponering. Denne artikel beskriver, hvordan man fører minimal erythema dosis (MED) test. Der er i øjeblikket ingen nem måde at afgøre en passende UV-dosis til kliniske eller forskningsformål uden at foretage en formel MED test, der kræver observation timer efter testning, eller uformelt trial and error test med risikoen for under-eller over-dosering. Der er dog nogle alternative metoder diskuteres.

<img alt="Figur 1" fo:content-width="4in" fo:src="/files/ftp_upload/50175/50175fig1highres.jpg" src="/files/ftp_upload/50175/50175fig1.jpg" /> Figur 1. De fire trin i ledende MED test:. Forberede UV-eksponering, gennemføre UV-eksponering, vurdere MED og fastlæggelse af MED. <img alt="Figur 2" src="/files/ftp_upload/50175/50175fig2.jpg" /><p class="jove_content" fo:keep-toge...

Watch this Scientific Journal Video about Minimal Erythema Dose MED Testing at JoVE.com

Minimal Erythema Dose MED Testing

Denne artikel beskriver, hvordan man fører minimal erythema dosis (MED) testning for at bestemme den laveste dosis af ultraviolet stråling, der vil forårsage erytem (brænding), når det gives til et individ.

Minimal Erythema Dose (MED) Test

Ultraviolet radiation (UV) therapy is  sometimes used as a treatment for various common skin conditions, including  psoriasis, acne, and eczema. The ...

Research

JoVE Journal

Medicine

Minimal Erythema Dose (MED) Testing

Quantitative Autonomic Testing

Disorders associated with dysfunction of autonomic nervous system are quite common yet frequently unrecognized. Quantitative autonomic testing can be ...

X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging

X-ray fluoroscopy is widely used for image guidance during cardiac intervention. However, radiation dose in these procedures can be high, and this is a ...

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Forberedelse og Pathogen Inaktivering af dobbelt dosis buffy coat Trombocyttal Produkter med INTERCEPT Blood System

Blood centers are faced with many challenges including maximizing production yield from the blood product donations they receive as well as ensuring the ...

A Novel Application of Musculoskeletal Ultrasound Imaging

A Novel Anvendelse af Muskuloskeletal Ultralydbilleddannelse

Ultrasound is an attractive modality for imaging muscle and tendon  motion during dynamic tasks and can provide a complementary methodological  approach ...

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

Frivillig Breath-hold teknik til reduktion Heart Dose i venstre bryst strålebehandling

Breath-holding techniques reduce the amount of radiation received by cardiac structures during tangential-field left breast radiotherapy. With these ...

Minimal Invasive Surgical Procedure of Inducing Myocardial Infarction in Mice

Minimal Invasive Kirurgisk Procedure inducere myokardieinfarkt i mus

Myocardial infarction still remains the main cause of death in western countries, despite considerable progress in the stent development area in the last ...

Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders

Intrakoronar Acetylcholin Provokation Test for vurdering af koronar Vasomotoriske Disorders

Intracoronary acetylcholine provocation testing (ACH-test) is an established method for assessment of epicardial coronary artery spasm in the ...

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement

Teknik og patienten udvælgelseskriterier af højre forreste mini torakotomi for Minimal Access aortaklappen udskiftning

Aortic valve stenosis has become the most prevalent valvular heart disease in developed countries, and is due to the aging of these populations. The ...

Precision Implementation of Minimal Erythema Dose (MED) Testing to Assess Individual Variation in Human Inflammatory Response

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Præcision implementering af minimal erythema dose (MED) test til vurdering af individuel variation i menneskelig inflammatorisk respons

Minimal erythema dose (MED) testing is frequently used in clinical settings for determining the smallest amount of ultraviolet (UV) irradiation necessary ...

A Training and Testing System for Performing Vascular Reconstruction In Vitro

Et trænings-og test system til udførelse af vaskulær rekonstruktion in vitro

Manual vascular reconstruction training is essential for a beginner surgeon. However, an optimal training system for vascular reconstruction in vitro has ...