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58.8K Views
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14:55 min
May 12th, 2013
DOI :
10.3791/50326-v
Chapters
0:05
Title
1:54
Pre-Surgical Procedure
3:49
Implantation of Alzet Osmotic Pump
8:01
Changing or Removing Alzet Osmotic Pump
9:51
Administration of an Intracerebroventricular Bolus
12:12
Results: Intraventricular Delivery of Antisense Oligonucleotides to the Rodent Central Nervous System
14:36
Conclusion
Summary
我们描述了一种方法,目标通过植入导管或进行大剂量注射到在小鼠右侧脑室中枢神经系统的药物。我们特别专注于交付反义寡核苷酸。这种技术是很容易适应其他药物和大鼠。
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