Name: process of making three-dimensional microstructures using vaporization of a sacrificial component
Uploaded: 2013-11-02T17:00:00
Description: Watch this Scientific Journal Video about Process of Making Three-dimensional Microstructures using Vaporization of a Sacrificial Component at JoVE.com

AFOSR青年研究者计划下FA9550-12-1-0352和3M非终身制教师奖，这项工作是支持。笔者想，感谢Lalisa Stutts和Janine汤姆有益的讨论，有关这个项目的。作者感谢的Calit2显微镜中心和激光光谱学设施，尔湾加州大学允许使用其设施。霍奇哈兰德与UCI物理科学车间公认的制作工具。聚（乳酸）乳酸纤维帝人单丝慷慨提供。

1。催化牺牲纤维<ol><li>包装所需量的聚（乳酸）乳酸纤维围绕降低¾定制的主轴。减少纤维的重叠，以提供最大的表面积暴露。 </li><li>剂Disperbyk 130在一个封闭的瓶用40ml去离子H 2 O混合并摇动，直到获得均匀的溶液。然后将1000毫升烧杯中，在37℃水浴中，并放入烧杯中倒入三氟。 H 2 O和TFE使用量取决于，PLA纤维直径。 <table border="1"><tbody><tr><td> 光纤直径 </td><td> ...

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	<li>Bellan, L. M., Singh, S. P., Henderson, P. W., Porri, T. J., Craighead, H. G., Spector, J. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Fabrication+of+an+artificial+3-dimensional+vascular+network+using+sacrificial+sugar+structures.">Fabrication of an artificial 3-dimensional vascular network using sacrificial sugar structures.</a> Soft Matter. 5 (7), 1354 (2009).</li><li>Bellan, L. M., Strychalski, E. A., Craighead, H. G. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Nano-channels+fabricated+in+polydimethylsiloxane+using+sacrificial+electrospun+polyethylene+oxide+nanofibers.">Nano-channels fabricated in polydimethylsiloxane using sacrificial electrospun polyethylene oxide nanofibers.</a> J. Vac. Sci. Technol. B Microelectron. Nanometer Struct. Process. Meas. Phenom. 26 (5), 1728 (2008).</li><li>Borenstein, J. T., Weinberg, E. J., Orrick, B. K., Sundback, C., Kaazempur-Mofrad, M. R., Vacanti, J. P. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Microfabrication+of+three-dimensional+engineered+Scaffolds.">Microfabrication of three-dimensional engineered Scaffolds.</a> Tissue Eng. 13 (8), 1837-1844 (2007).</li><li>Wu, H., Odom, T. W., Chiu, D. T., Whitesides, G. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Fabrication+of+complex+three-dimensional+microchannel+systems+in+PDMS.">Fabrication of complex three-dimensional microchannel systems in PDMS.</a> J. Am. Chem. Soc. 125 (2), 554-559 (2003).</li><li>Trask, R. S., Bond, I. P. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Biomimetic+self-healing+of+advanced+composite+structures+using+hollow+glass+fibres.">Biomimetic self-healing of advanced composite structures using hollow glass fibres.</a> Smart Mater. Struct. 15 (3), 704-710 (2006).</li><li>Dong, H., Esser-Kahn, A. P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Chemical+treatment+of+poly(lactic+acid)+fibers+to+enhance+the+rate+of+thermal+depolymerization.">Chemical treatment of poly(lactic acid) fibers to enhance the rate of thermal depolymerization.</a> ACS Appl. Mater. Interfaces. 4 (2), 503-509 (2012).</li><li>Esser-Kahn, A. P., Thakre, P. R., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Three-dimensional+microvascular+fiber-reinforced+composites.">Three-dimensional microvascular fiber-reinforced composites.</a> Adv. Mater. 23 (32), 3654-3658 (2011).</li><li>White, S. R., Blaiszik, B. J., Kramer, S. L. B., Olugebefola, S. C., Moore, J. S., Sottos, N. R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Self-healing+polymers+and+composites.">Self-healing polymers and composites.</a> Am. Sci. 99 (5), 392 (2011).</li><li>Nguyen, D. T., Leho, Y. T., Esser-Kahn, A. P. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+three-dimensional+microvascular+gas+exchange+unit+for+carbon+dioxide+capture.">A three-dimensional microvascular gas exchange unit for carbon dioxide capture.</a> Lab Chip. 12 (7), 1246 (2012).</li><li>Nguyen, D. T., Leho, Y. T., Esser-Kahn, A. P. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+effect+of+membrane+thickness+on+a+microvascular+gas+exchange+unit.">The effect of membrane thickness on a microvascular gas exchange unit.</a> Adv. Funct. Mater. , (2012).</li></ol>

的SNOX催化剂的成聚乳酸纤维的引入允许在较低温度下的纤维的解聚。这可以防止嵌入树脂的降解，在这种情况下的PDMS。一个自定义的主轴需要正确地混合处理液（ 图5A）。主轴由六个支撑棒附加到数字混频器的中心纤芯周围。将纤维缠与催化剂溶液接触的包装的纤维的表面积最大化，使支承杆。包含主轴的底部一组叶片引入混沌流动。的乱流，防止附聚的催化剂。 <p class="jove_cont...

自然系统使用广泛的血管网络，方便许多生物功能。大众运输可以有效地实现，在这种系统中，由于高的表面积与体积比和优化包装结构。虽然许多合成制造技术可以产生微血管结构，没有人能生产大型微血管的复杂性和兼容性，同时保持与现有的制造方法1-5。如禽流肺的结构提供了灵感。我们如何制造这种复杂的结构，提高大众交通工具吗？ 汽化牺牲组件（VASC）的生产规模大，复杂的微血管结构6-7。此方法使用的热解聚和聚（乳酸）乳酸纤维，形成中空纤维模板的逆通道的蒸发除去。这是一个牺牲的技术与现有的制造的方法。米长，可以使用此制造过程中形成的圆筒状微通道型态。这可以被用来创建血管化设备，如自愈7至10的聚合物和三维微血管碳捕获单元。 碳捕获单元灵感禽流肺，提供了一个有效的气体交换 - 重量比，由于在飞行途中使用。 parabronchus组成的六边形图案的微通道，它提供了高瓦斯汇率和结构稳定的气体交换单位。为了创建交换单元微型三维对齐功能，我们开发了使用自定义吉他调谐器和激光微加工板设计张力板独立拉紧纤维的方法。每根纤维由外部的张力保持在适当位置，由放置在板中的孔，通过该纤维的运行模式被设置。

<table border="1">
	<tbody>
		<tr>
			<td></td>
			<td></td>
			<td></td>
			<td>Reagent</td>
		</tr>
		<tr>
			<td>Tin (II) oxalate</td>
			<td>Sigma-Aldrich</td>
			<td>402761</td>
			<td></td>
		</tr>
		<tr>
			<td>Disperbyk 130</td>
			<td>BYK Additives &#38; Instruments</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Trifluoroethanol</td>
			<td>Halocarbon</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Malachite Green (technical grade)</td>
			<td>Sigma-Aldrich</td>
			<td>M6880</td>
			<td></td>
		</tr>
		<tr>
			<td>Sodium hydroxide (&#8805;98%, pellets)</td>
			<td>Sigma-Aldrich</td>
			<td>S5881</td>
			<td></td>
		</tr>
		<tr>
			<td>Polydimethylsiloxane (PDMS)</td>
			<td>Dow Corning</td>
			<td>3097358-1004</td>
			<td>Distributed from Ellsworth Adhesives</td>
		</tr>
		<tr>
			<td>Poly(lactic) acid fibers</td>
			<td>Teijin Monofilament</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td></td>
			<td></td>
			<td></td>
			<td>Material</td>
		</tr>
		<tr>
			<td>RW 20 Digital Mixer</td>
			<td>IKA</td>
			<td>3593001</td>
			<td></td>
		</tr>
		<tr>
			<td>Desiccator Jar</td>
			<td>Pyrex</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Vacuum Oven</td>
			<td>Fisher Scientific</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Third Hand</td>
			<td>Jameco Electronics</td>
			<td>26690</td>
			<td>Plate holder</td>
		</tr>
		<tr>
			<td>Glue Gun</td>
			<td>Stanley</td>
			<td>GR20L</td>
			<td></td>
		</tr>
		<tr>
			<td>PLA Spindle</td>
			<td></td>
			<td></td>
			<td>Custom made</td>
		</tr>
		<tr>
			<td>Tensioning Board</td>
			<td></td>
			<td></td>
			<td>Custom made</td>
		</tr>
	</tbody>
</table>

process of making three-dimensional microstructures using vaporization of a sacrificial component

在自然系统中的血管结构通过高比表面积和优化结构，能够提供高质量传输。几个合成材料制造技术保持可扩展性的同时，能够模拟这些结构的复杂性。汽化一个祭祀元器件（VASC）的过程是能够做到这一点。此过程中使用牺牲纤维作为模板，以形成空心的圆筒形的嵌入在一个矩阵中的微通道。锡（II），草酸（SNOX）的嵌入于聚（乳酸）乳酸（PLA）纤维，在此过程中有利于使用。的的SNOX催化解聚的聚乳酸纤维在较低温度下。乳酸的单体气体在这些温度下，可以在不损伤基体的温度从嵌入的矩阵除去。在这里，我们使用微机械板和张紧装置来创建复杂的三维排列的微通道模式使这些纤维的方法。该过程允许任意排列的纤维的探索拓扑和结构。

本程序提供了嵌入树脂中的微血管结构的制造方法。这些结构可以符合各种图案（ 图2）。仅受限于微血管网络的结构，可以形成与牺牲纤维结构。 使用平行排列的微血管通道，流体流的气体之间的运输容易气体遍历信道间的可渗透膜。这些设备可以在一个可扩展的方式制造的光刻而不需要（ 图3）。所形成的微通道是完全空心的，可以相隔小于50μm?...

Watch this Scientific Journal Video about Process of Making Three-dimensional Microstructures using Vaporization of a Sacrificial Component at JoVE.com

Process of Making Three-dimensional Microstructures using Vaporization of a Sacrificial Component

的汽化一个祭祀元器件（VASC）的过程中，用于制造微血管结构。此过程使用牺牲聚乳酸纤维（乳酸），形成空心微所提供的激光微加工导光板的精确的三维几何定位。

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Vascular structures in natural systems are able to provide high mass transport through high surface areas and optimized structure. Few synthetic material ...

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Predicting Catalyst Extrudate Breakage Based on the Modulus of Rupture

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The mechanical strength of extruded catalysts and their natural or forced breakage by either collision against a surface or by a compressive load in a ...

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Ultrasound is frequently used for guiding minimally invasive procedures, but visualizing medical devices is often challenging with this imaging modality. ...