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Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

6.0K Views

12:38 min

December 18th, 2013

December 18th, 2013

6,023 Views

0:05

Title

1:20

Monitoring Behavior by Thermo-resistance

2:35

Monitoring Protein Localization by Immunostaining

7:39

Monitoring Protein Folding and Stability by Partial Digestion

9:46

Monitoring Protein Folding and Stability in a Multicellular Organism

12:11

Conclucion

To study the relationship between protein homeostasis, stress and aging, we monitored changes in protein folding by following protein dysfunction, protein localization in the cell and protein stability at the organismal, cellular and protein levels, using the genetically tractable metazoan Caenorhabditis elegans as a model system.

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