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08:09 min
January 7th, 2014
DOI :
10.3791/50960-v
Chapters
0:05
Title
1:25
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) Preparation
3:50
MPTP Administration
5:59
Results: 5-LOX and 12/15-LOX Differentially Impact the Nigrostriatal Dopaminergic Vulnerability
7:40
Conclusion
Summary
脂氧酶 (LOX) 异酶可以产生可能增加或减少神经发炎和神经退化的产品。基因-环境相互作用研究可以识别LOX异位素特异性效应。使用1-甲基-4-苯-1,2,3,6-四氢皮里丁(MPTP)模型的硝基丙烯损伤在两个LOX异酶缺乏转基因线允许比较LOX异位素对多巴胺完整性和炎症的贡献。
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