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32.5K Views
•
07:23 min
July 29th, 2014
DOI :
10.3791/51264-v
Chapters
0:05
Title
1:24
Tail Immersion Test (TIT)
2:39
Tail Pressure Test (TPT)
3:31
Acute Morphine-induced Analgesia
4:42
Chronic Morphine Treatment
5:32
Results: Morphine-induced Hyperalgesia and Analgesic Tolerance
6:48
Conclusion
Summary
我们描述了一个协议,研究阿片类药物引起的痛觉过敏和耐受小鼠的发展。基于对幼稚和吗啡处理的动物的热和机械伤害性反应的测量,它允许以量化的增加疼痛的敏感性(痛觉过敏)和减少在慢性阿片类施用相关镇痛(公差)。
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