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Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles

DOI :

10.3791/52323-v

January 22nd, 2015

January 22nd, 2015

12,133 Views

1Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 2Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care, Boston Children's Hospital

The objective of this protocol is to incorporate SDF-1α, a stem cell homing factor, into dextran sulfate-chitosan nanoparticles. The resultant particles are measured for their size and zeta potential, as well as the content, activity, and in vitro release rate of SDF-1α from the nanoparticles.

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