Функциональная оценка биологического нейротоксинов в сетевых культур стволовых клеток, полученных Центральная нервная система Нейроны

A custom protocol is described to differentiate mouse ES cells into defined populations of highly pure neurons exhibiting functioning synapses and emergent network behavior. Electrophysiological analysis demonstrates the loss of synaptic transmission following exposure to botulinum neurotoxin serotypes /A-/G and tetanus neurotoxin.