Introducer Sheath for Pulmonary Artery Catheter, Central Venous Line and Arterial Catherter Placement
3:02
Pulmonary Artery Catheter (PAC) Introduction
4:05
Pulmonary Artery Thermodilution Technique and Hemodynamic Measurements
4:52
Surfactant Depletion by Lung Lavage
6:09
Results: Representative PaO2/FIO2 Ratios and MPAP for Three Pigs
6:40
Conclusion
Transcript
The goal of this method is to create a model of acute respiratory failure using a pulmonary surfactant washout to induce lung atelectasis, hypoxemia, and pulmonary hypertension, important pathophysiological aspects of human acute respiratory distr
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Repeated pulmonary lavages in anesthetized pigs induce lung injury resembling major aspects of human acute respiratory distress syndrome (ARDS). For this purpose the lungs are repeatedly lavaged with 0.9% saline at 37 °C. The goal of the protocol is a reproducible mitigation of gas exchange and hemodynamics for research in ARDS.