Construction of Humanized Mice Engineered with CD4 Chimeric Antigen Receptor: Thymus Processing
2:18
Liver Processing
5:18
Tissue Transplantation to Construct Genetically Engineered Mice
9:28
Results: Characteristics of CD4 Chimeric Antigen Receptor Modified Cells
10:39
Conclusion
Transcript
The overall goal of this procedure is to create humanized mouse modified with chimeric antigen receptor. This method can help answer key questions in the HIV and immunology fields in regards to testing the efficacy of stem-cell based engineered im
Sign in or start your free trial to access this content
This protocol describes the methods in constructing a humanized bone-marrow/liver/thymus mouse model with stem cell-based engineered immunity against HIV infection.