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Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques

DOI :

10.3791/54060-v

June 1st, 2016

June 1st, 2016

10,789 Views

1Neurosciences Axis, CHU de Québec Research Center

This article describes a protocol for visualizing amyloid Aβ plaques in Alzheimer's disease mouse models using methoxy-X04, which crosses the blood-brain barrier and selectively binds to β-pleated sheets found in dense core Aβ plaques. It allows pre-screening of plaque-containing tissue sections prior to immunostaining and processing for electron microscopy.

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