Creazione di Sub-50 Nm nanofluidic giunzioni in PDMS Microfluidic Chip tramite processo di auto-assemblaggio di particelle colloidale

We propose a simple self-assembly technique of silica colloidal nanoparticles to create a nanofluidic junction between two microchannels in polydimethylsiloxane (PDMS). Using this technique, a nanoporous bead membrane with a pore size down to ~45 nm was built inside a microchannel and applied to electrokinetic preconcentration of DNA samples.