Des outils pour étudier le rôle de l'architecture Protein HMGB1 dans le traitement des Helix effets de distorsion, l'ADN spécifique du site InterStrand Crosslinks

Targeted DNA damage can be achieved by tethering a DNA damaging agent to a triplex-forming oligonucleotide (TFO). Using modified TFOs, DNA damage-specific protein association, and DNA topology modification can be studied in human cells by the utilization of modified chromatin immunoprecipitation assays and DNA supercoiling assays described herein.