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An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

DOI :

10.3791/54750-v

12:02 min

November 2nd, 2016

November 2nd, 2016

11,576 Views

1Department of Chemistry, Durham University, 2School of Medicine, Pharmacy and Health, Durham University

A protocol to synthesize peptoids with mixed cationic functionality in the same sequence is presented (lysine- and arginine-type monomers). Subsequent testing of these compounds against Leishmania mexicana, the protozoan parasites that cause cutaneous leishmaniasis, is also described.

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Keywords Peptoids

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