Name: ultrasonographic evaluation of breast cancer-related lymphedema
Uploaded: 2017-01-12T13:00:00
Description: Watch this Scientific Journal Video about Ultrasonographic Evaluation of Breast Cancer-related Lymphedema at JoVE.com

The authors have nothing to acknowledge.

Tutte le procedure sono stati rivisti e approvati dal Institutional Review Board della Chungnam National University Hospital. 1. Misura con ecografia <ol><li> Impostare la postura del paziente. <ol><li> Posizionare il braccio del paziente in posizione supina, con entrambe le braccia sul letto. </li></ol></li><li> Determinare i siti di misurazione sulla parte superiore del paziente. <ol><li> Mark nel punto centrale della piega del polso, il punto intermedio tra il mediale e epicondili laterali a livello del gom...

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	<li>Lasinski, B. B. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Complete+decongestive+therapy+for+treatment+of+lymphedema.">Complete decongestive therapy for treatment of lymphedema.</a> Seminars in Oncology Nursing. 29 (1), 20-27 (2013).</li><li>Clark, B., Sitzia, J., Harlow, W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Incidence+and+risk+of+arm+oedema+following+treatment+for+breast+cancer:+a+three-year+follow-up+study.">Incidence and risk of arm oedema following treatment for breast cancer: a three-year follow-up study.</a> Q J Med. 98 (5), 343-348 (2005).</li><li>Hayes, S. C., Speck, R. M., Reimet, E., Stark, A., Schmitz, K. 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G. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Ultrasonography+in+the+Evaluation+of+Breast+Cancer-Related+Lymphedema.">Ultrasonography in the Evaluation of Breast Cancer-Related Lymphedema.</a> Lymphatic Research and Biology. 14 (1), 1 (2016).</li><li>Suehiro, K., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Significance+of+Ultrasound+Examination+of+Skin+and+Subcutaneous+Tissue+in+Secondary+Lower+Extremity+Lymphedema.">Significance of Ultrasound Examination of Skin and Subcutaneous Tissue in Secondary Lower Extremity Lymphedema.</a> Ann Vasc Dis. 6 (2), 180-188 (2013).</li><li>Lee, J. H., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Ultrasonographic+Evaluation+of+Therapeutic+Effects+of+Complex+Decongestive+Therapy+in+Breast+Cancer-Related+Lymphedema.">Ultrasonographic Evaluation of Therapeutic Effects of Complex Decongestive Therapy in Breast Cancer-Related Lymphedema.</a> Ann Rehabil Med. 37 (5), 683-689 (2013).</li><li>DiSipio, T., Rye, S., Newman, B., Hayes, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Incidence+of+unilateral+arm+lymphoedema+after+breast.">Incidence of unilateral arm lymphoedema after breast.</a> Lancet Oncol. 14 (6), 500-515 (2013).</li><li>Stanton, A. W., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Lymphatic+drainage+in+the+muscle+and+subcutis+of+the+arm+after+breast+cancer+treatment.">Lymphatic drainage in the muscle and subcutis of the arm after breast cancer treatment.</a> Breast Cancer Res Treat. 117 (3), 549-557 (2008).</li><li>Godoy, M. F. G., Pereira, M. R., Oliani, A. H., Godoy, J. M. P. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Synergic+Effect+of+Compression+Therapy+and+Controlled+Active+Exercises+Using+a+Facilitating+Device+in+the+Treatment+of+Arm+Lymphedema.">Synergic Effect of Compression Therapy and Controlled Active Exercises Using a Facilitating Device in the Treatment of Arm Lymphedema.</a> Int J Med Sci. 9 (4), 280-284 (2012).</li><li>Cormie, P., Pumpa, K., Galv&#227;o, D. A., Turner, E., Spry, N., Saunders, C., Zissiadis, Y., Newton, R. U. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Is+it+safe+and+efficacious+for+women+with+lymphedema+secondary+to+breast+cancer+to+lift+heavy+weights+during+exercise:+a+randomised+controlled+trial.">Is it safe and efficacious for women with lymphedema secondary to breast cancer to lift heavy weights during exercise: a randomised controlled trial.</a> J Cancer Surviv. 7 (3), 413-424 (2013).</li><li>Bok, S. K., Jeon, Y., Hwang, P. 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Le valutazioni di BCRL possono essere condotte attraverso varie tecniche, tra cui circonferenze del braccio di misurazione del nastro, misura dello spostamento d&#39;acqua, la spettroscopia bioimpedenza, perometry (volumetro optoelettronica), linfoscintigrafia, la diagnosi medico, o gonfiore self-report da parte del paziente. Tuttavia, non esistono standard per la misurazione della BCRL; la diagnosi e la durata del trattamento può essere determinato empiricamente in vari modi, a seconda della clinica. <p class="jov...

Linfedema è definita come una condizione di localizzato ricca di proteine ritenzione idrica e gonfiore dei tessuti causate da un 1,2 sistema linfatico compromessa. Come linfedema progredisce, fibrociti e / o adipociti proliferano nelle zone colpite, che porta a cambiamenti nella struttura della pelle e del tessuto sottocutaneo e una maggiore vulnerabilità alle infezioni batteriche e fungine 3,4. L&#39;osservazione di questi cambiamenti in varie parti degli arti può chiarire ulteriormente la gravità e l&#39;estensione del linfedema. Il sistema linfatico sottofasciale contribuisce alla gravità del linfedema più del sistema linfatico epifasciale. Recenti ricerche hanno riguardato principalmente l&#39;uso dell&#39;ecografia nella diagnosi di linfedema 5,6. L&#39;ecografia è un metodo relativamente poco costoso per osservare le caratteristiche dei tessuti molli. Un precedente studio ha riportato che linfedema può essere attendibilmente diagnosticato con ecografia confrontando tha spessore del tessuto cutaneo e sottocutaneo e anche valutando la conformità del tessuto sottocutaneo in un ambiente 7,8 clinica. Inoltre, ecografia è ampiamente usato in clinica per la sua facile accessibilità, di sicurezza da esposizione a radiazioni, ed economicità 5,6. A dispetto di questi benefici, gli studi sulla ecografia per linfedema solo sono stati concentrati sulla diagnosi, non sulla valutazione degli interventi terapeutici. Pertanto, lo studio mirato a determinare non solo l&#39;utilità dell&#39;ecografia nel chiarire gli effetti di PRE sulla BCRL, ma anche se ultrasonografia ha un significato clinico come test di follow-up nel confermare l&#39;efficacia del trattamento. Questo studio è stato condotto per stabilire il protocollo per ultrasuoni eseguiti per esaminare linfedema.

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			<td>Eco Gel 99</td>
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ultrasonographic evaluation of breast cancer-related lymphedema

Linfedema è una delle più comuni complicanze dopo chirurgia del cancro al seno. Ci sono molti strumenti diagnostici per linfedema, ma nessun metodo standard ancora esiste. Progressive Resistenza Esercizio (PRE) dovrebbe migliorare linfedema senza gonfiore aggiuntivo. Questo studio ha mostrato effetti terapeutici di PRE sul linfedema mediante ecografia per misurare la variazione di spessore del muscolo e del tessuto sottocutaneo. Lo spessore del tessuto sottocutaneo è diminuito di più nel gruppo PRE che nel gruppo non-PRE. L&#39;ecografia è ampiamente usato in molte cliniche per la sua facile accessibilità, la sicurezza, ed economicità. L&#39;ecografia è uno dei migliori strumenti per la diagnosi e la determinazione l&#39;efficacia del trattamento sul linfedema al seno per cancro (BCRL).

Questo studio ha incluso 32 pazienti con diagnosi di BCRL. Lo spessore del muscolo e del tessuto sottocutaneo e le circonferenze degli arti superiori prossimale e distale sono stati misurati al basale, 4 settimane e 8 settimane dopo PRE. Esaminatori misurato la circonferenza degli arti superiori con un nastro misura, e quindi lo spessore del muscolo e del tessuto sottocutaneo sono stati misurati mediante ecografia. I pazienti sono stati divisi casualmente in un gruppo PRE e un gruppo non...

Watch this Scientific Journal Video about Ultrasonographic Evaluation of Breast Cancer-related Lymphedema at JoVE.com

Ultrasonographic Evaluation of Breast Cancer-related Lymphedema

Questo studio ha utilizzato l&#39;ecografia per la diagnosi e test di follow-up per confermare l&#39;efficacia del trattamento di progressiva resistenza esercizio (PRE) in linfedema al seno per cancro (BCRL). L&#39;ecografia può essere applicato in modo efficace per garantire la diagnosi e il trattamento del linfedema.

Ecografica Valutazione del seno Linfedema correlati al cancro

Lymphedema is one of the most common complications after breast cancer surgery. There are many diagnostic tools for lymphedema, but no standard method yet ...

The overall goal of this procedure is to diagnose breast cancer-related lymphedema and evaluate the therapeutic effect of resistive exercise by using ultrasonography to measure the thickness of subcutaneous tissue. Begin by laying the patient's arm in a supine position with both arms on the bed. Use a pen to mark the midpoint of the wrist crease, the midpoint of the medial and lateral epicondyles at the level of the elbow, in the bicipital groove.Then connect these points using a ruler. Next, mark the first target area 10 centimeters proximal to the elbow point along the line between the elbow and bicipital groove. In the second target area, 10 centimeters distal to the elbow point along the line between the elbow and the wrist.Then, switch on the ultrasound system. Enter the 2-D mode of the soft tissue via the keyboard. Set the depth to five centimeters and choose the 14L5 linear array transducer.Apply sufficient gel to the ultrasound transducer and place it perpendicularly to the upper limb ventral axis. The short axis view to capture the image where the thickness of the gel is at least one centimeter and the soft tissue contours are not distorted. Next, select the calibrator and the software via the keyboard of the ultrasounds system to draw a line between the muscle and the subcutaneous tissue.Then, measure the thickness of the muscle, defined at the distance between the highest point on the boundary of the bone to the highest point on the boundary portion of the fascia. Finally, measure the thickness of the subcutaneous tissue, defined as the distance from the skin to the fascia. After measuring the upper limb muscle and subcutaneous tissue thickness at baseline, give the patient a 5 kilogram dumbbell and have him or her put on a compression stocking.Ask the patient to perform the progressive resistant exercises, or PRE, in the following order. Dumbbell fly, tricep extension, one arm bent-over row, bicep curls, dumbbell side raise, and lifting the arms forward. Next, instruct the patient to complete the six exercises twice a day according to the following schedule.Five times each during the first week, 10 times each during the second week, 15 times each during the third week, 20 times each during the forth week, and 25 times each during the fifth through eighth weeks. Inform the subject to return at four and eight weeks later to measure the thickness of the subcutaneous tissue and muscle of the upper limb again. Finally, after all measurements are collected, analyze the data by comparing the difference between both arms using a paired T test.Compare the changes in subcutaneous tissue and muscle thickness using a repeated measures ANOVA. According to the tape measurement, arm circumference did not significantly change in the PRE group after four weeks of exercise. However, both proximal and distal arm circumferences showed a significant reduction after eight weeks.As measured by ultrasonography in the PRE group, the thickness of muscle in the distal part showed a significant increase at four weeks and eight weeks. and the proximal part demonstrated a significant increase in thickness at eight weeks. Lastly, in the PRE group, the thickness of subcutaneous tissue in the affected upper limb significantly decreased after eight weeks.No significant difference in these parameters was observed in the control group.

Research

JoVE Journal

Cancer Research

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Utilizzando Genomica Funzionale screening per identificare gli obiettivi farmaco potenzialmente romanzo in Cancer Cell Culture Spheroid

The identification of functional driver events in cancer is central to furthering our understanding of cancer biology and indispensable for the discovery ...

Ricerca

Ricerca sul cancro

A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer

Un modello di iniezione vena porta del fegato per studiare metastasi del cancro al seno

Breast cancer is the leading cause of cancer-related mortality in women worldwide. Liver metastasis is involved in upwards of 30% of cases with breast ...

Invasive Behavior of Human Breast Cancer Cells in Embryonic Zebrafish

Invasiva comportamento delle cellule cancro al seno umano in Zebrafish embrionali

In many cases, cancer patients do not die of a primary tumor, but rather because of metastasis. Although numerous rodent models are available for studying ...

Live-imaging of Breast Epithelial Cell Migration After the Transient Depletion of TIP60

Live-imaging della migrazione delle cellule epiteliali della mammella dopo lo svuotamento transitorio di TIP60

The wound-healing assay is efficient and one of the most economical ways to study cell migration in vitro. Conventionally, images are taken at the ...

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Valutare il ruolo della funzione mitocondriale in affaticamento legato al cancro

Fatigue is a common and debilitating condition that affects most cancer patients. To date, fatigue remains poorly characterized with no diagnostic test to ...

Orthotopic Injection of Breast Cancer Cells into the Mice Mammary Fat Pad

Orthotopic iniezione delle cellule di cancro al seno in topi cuscinetto grasso mammario

A proper animal model is crucial for a better understanding of diseases. Animal models established by different methods (subcutaneous injections, ...

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Ottenere le sfere delle cellule staminali tumorali da tumori ginecologici e tumori del cancro

Cancer stem cells (CSC) are a small population with self-renewal and plasticity which are responsible for tumorigenesis, resistance to treatment and ...

Differentiation of Mouse Breast Epithelial HC11 and EpH4 Cells

Differenziazione delle cellule epiteliali del seno del topo HC11 e EpH4

Cadherins play an important role in the regulation of cell differentiation as well as neoplasia. Here we describe the origins and methods of the induction ...