Ultraljud-guidad intrakardiellt injektion av humana mesenkymala stamceller att öka Homing till tarmen för användning i murina modeller av experimentella inflammatoriska tarmsjukdomar
September 1st, 2017
•Maneesh Dave1, Paola Menghini1, Keiki Sugi2,3, Rodrigo A. Somoza5, Zhenghong Lee4, Mukesh Jain2,3, Arnold Caplan5, Fabio Cominelli1
1Division of Gastroenterology and Liver Disease, University Hospitals, Digestive Health Research Institute, Case Western Reserve University, 2Case Cardiovascular Research Institute, School of Medicine, Case Western Reserve University, 3Department of Medicine, Harrington Discovery Institute, Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, 4Department of Radiology, University Hospitals Case Medical Center, 5Department of Biology - Skeletal Research Center, Case Western Reserve University
Murina studier i modeller av kolon inflammation har visat att en liten andel (1-5%) av mesenkymala stamceller (MSC) injiceras intravenöst eller intraperitonealt hem till den inflammera kolon1,2. Denna studie visar att ultraljud-guidad intrakardiellt injektioner av MSCs resultera i ökad lokalisering till tarmen.
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