Culture of THP-1 Reporter Cell-derived Macrophages
3:45
Screening for Potential TLR4 Nano-inhibitors Using the Reprter Cells
7:22
Results: Inhibition of Toll-like Receptor Signaling
9:13
Conclusion
Transcript
The overall goal of this screening procedure is to identify novel bioactive nanoparticles that can inhibit toll-like receptor signaling. This method can help you physically identify novel nanoinhibitors targeting toll-like receptor signaling in in
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Toll-like receptor (TLR) signaling plays an important role in the pathophysiology of many human inflammatory diseases, and regulating TLR responses by bioactive nanoparticles is anticipated to be beneficial in many inflammatory conditions. THP-1 cell-based reporter cells provide a versatile and robust screening platform for identifying novel inhibitors of TLR signaling.