Name: recording horizontal saccade performances accurately in neurological patients using electro-oculogram
Uploaded: 2018-03-13T12:30:00
Description: Watch this Scientific Journal Video about Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram at JoVE.com

Terao 博士得到了日本教育、文化、体育、科学和技术部 (16K09709,16H01497) 科研项目资助的资助。由日本教育、文化、体育、科技部 (15H05881, 16H05322, 22390181 号) 的科研项目资助资助, 并获资助。由日本卫生部和福利部关于帕金森病最佳 rTMS 治疗研究委员会的赠款;以及日本卫生部和福利部肌张力障碍研究委员会。

在获得知情同意后, 本研究的所有实验程序均根据该机构的人类研究伦理委员会的指导方针予以批准和实施。
1. 准备主题和重新编码的空间
<ol><li>在一个低环境照明的房间里进行录音, 以允许足够的光线适应。</li>
	<li>有受试者坐在一个黑色的凹球形的屏幕上, 测量直径90厘米, 其中含有嵌入针孔的发光二极管 (led), 它作为扫视的固定点和目标。 注: led 在水平、垂直和倾斜的...

<ol>
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虽然目前的记录扫视的方法已成为 VOG, 但目前的研究表明, EOG 可以达到与 VOG 如果正确实现 (图 2) 的精度几乎相同。在记录水平扫视时, 目前的 EOG 方法与 VOG 有很好的相关性, 并且已在许多以前的研究中成功地使用了同一组12、13、14、15 ,16,<sup cl...

有三种主要的方法来记录眼球运动, 传统的 EOG, VOG 记录的视频跟踪系统, 和巩膜搜索线圈 (SSC) 方法。其中, EOG 自二十世纪七十年代以来经常用于记录患者的眼球运动, 因为它的简单性。该方法广泛应用于临床人群, 广泛应用于神经内科患者的诊断, 并提供了有关疾病的病理生理学的有用信息1,2, 3,4,5。此外, 它仍然是唯一的技术, 可用于记录眼球运动在睡眠期间 (快速眼球运动在 REM 睡眠和其他形式的眼球运动)。
由于眼球的前部, 包括角膜相对于其后部的正面充电, 有一个电压差的眼睛的前后方面称为 corneo 视网膜电位。由于这种电位的存在, 当受试者将目光转向右边时, 右电极会变得比左边更积极, 当他们把目光转向左边时, 就会变得消极。由于左、右电极之间的电压差与水平扫视的眼球旋转角度有显著的相关性, 因此可以用来测量水平眼运动。然而, 这种相关性并不能保持垂直方向, 虽然垂直 EOG 仍然可以用来测量眼球运动6。另一方面, 一些研究主要使用垂直 EOG 来监测眨眼。
然而, 最近, VOG 已经在很大程度上取代了 EOG, 因为它的空间准确性达到 0.25-0.5 度, 现在已经成为扫视记录在临床设置的标准方法。同时, EOG 已经被认为相当过时, 因为它的空间精度, 最多0.5 度, 不如 VOG。
然而, VOG 也有它自己的缺点, 如果使用在临床设置。有些情况下, VOG 是不可行的;例如, 眼睛的跟踪变得不准确的主题与狭窄的眼睛裂, 如当大面积的角膜被眼睑遮挡。在白内障晶状体患者中, 红外光的异常反射阻碍了对凝视方向的可靠记录。此外, EOG 可以提供一些人的优势, 他们的运动紊乱使 VOG 记录困难。此外, 与 EOG 的设置相比, VOG 系统更昂贵, 这往往使前者无法在普通医疗设施中使用。
另一方面, SSC 方法被认为是衡量眼球运动的黄金标准。与 VOG 和 EOG 相比, 该方法提供了最高的空间精度, 降低到0.1 度, 并且在录制涉及高频磁头运动6时尤其有用。但是, 此方法可能具有侵入性,即, 疼痛且对眼睛很刺激, 只允许录制一段简短的时间, 大约在30分钟或更短的7,8,9,10.虽然在某些专用设施中成功使用了11, 但这一短时间使其成为不适用于广泛临床应用的方法。
根据以前的研究记录了250多名神经症患者和480例正常人由同一组12,13,14,15,16,17, 18,19, 本研究表明, EOG 可以准确地作为一种标准的眼球运动记录技术, 广泛适用于临床人群, 同时规避 VOG 的各种弊端。和 SSC。本篇文章描述了一种稳定的 EOG 记录方法, 使用一个宽条纹电极, 允许与皮肤广泛和稳定的接触, 类似于脑电图电极安全地连接在头皮上的火棉胶记录了很长一段时间。电极的阻抗下降, 记录随着时间的推移变得稳定, 从而有效地减少了面部肌肉和脑电图的工件。该方法与同步记录 VOG 进行了比较。当适当的准备和实施, EOG 是一样好, VOG 在记录扫视在神经系统病人的准确性方面, EOG 甚至可能更适合扫视记录在正常的主题。

<table border="0" cellpadding="0" cellspacing="0" style="width:927px;" width="926">
	<colgroup>
		<col />
		<col />
		<col />
		<col />
	</colgroup>
	<tbody>
		<tr height="21">
			<td height="21" style="height:21px;width:297px;">Electrode</td>
			<td style="width:276px;">Nihon-Kohden (Tokyo, Japan)</td>
			<td style="width:119px;">NS111-115</td>
			<td style="width:235px;">cup electrode</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:297px;">Electrode paste</td>
			<td style="width:276px;">Nihon-Kohden (Tokyo, Japan)</td>
			<td style="width:119px;">Gelaid Z-101BA</td>
			<td>gel electrode paste to fill in the cup electrode</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:297px;">Adhesive tape&#160;</td>
			<td style="width:276px;">Nihon-Kohden (Tokyo, Japan)</td>
			<td style="width:119px;">H261</td>
			<td>double-stick tape for fixating the electrode</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:297px;">DC-amplifier</td>
			<td style="width:276px;">Nihon-Kohden (Tokyo, Japan)</td>
			<td style="width:119px;">AN-601G</td>
			<td>amplifier for EOG</td>
		</tr>
		<tr height="42">
			<td height="42" style="height:42px;">video-based eye tracking system</td>
			<td style="width:276px;">SR research (Mississauga, Ontario, Canada)</td>
			<td style="width:119px;">Eyelink II</td>
			<td>eye tracking system for recording VOG</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:297px;">Filter</td>
			<td style="width:276px;">NF corporation</td>
			<td style="width:119px;">MS-521</td>
			<td>filter for the EOG signal</td>
		</tr>
	</tbody>
</table>

recording horizontal saccade performances accurately in neurological patients using electro-oculogram

电 oculogram (EOG) 已被广泛应用于临床眼球运动记录, 尤其是水平扫视, 尽管视频 oculography (VOG) 在很大程度上取代了它现在的位置, 因为它的空间准确性较高。然而, 有些情况下, EOG 有明显的优势超过 VOG,例如,主题狭窄的眼睛裂或有白内障镜头, 和患者的运动障碍。本文表明, 如果适当地实现, EOG 可以达到的精度几乎一样好, VOG 具有相当稳定的记录, 同时规避与 VOG 记录相关的问题。本文介绍了一种实用的方法, 用 EOG 在神经质患者中使用高准确度和稳定性的动眼神经范式记录水平扫视。必要的措施是使用 AgCl 电极与宽塑料边缘能减少噪声, 并且等待充足的光适应发生。这个等待期也有助于降低电极和皮肤之间的阻抗, 从而确保稳定的信号记录随着时间的推移。此外, 在任务执行过程中需要重新校准。利用该方法, 实验者可以避免信号的漂移, 以及从肌电和脑电图中产生的工件或噪声的污染, 为扫视的临床评价收集足够的数据。因此, EOG 仍然可以是一种高实用性的方法, 可以广泛应用于神经学患者, 但也可能对正常人的研究有效。

图 2显示了正常主题中 EOG 和 VOG 的具有代表性的同时记录。对 VGS 的8项试验叠加 EOG (灰色曲线) 和 VOG (红色曲线;图 2A). 通过本方法标定, EOG 和 VOG 数据在5-30 度范围内是线性的, 数据的空间精度为0.5 度。
这两种方法取得的记录基本上是相互重叠的。此外, 扫视参数 (如滞?...

Watch this Scientific Journal Video about Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram at JoVE.com

Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram

用电 oculogram 准确记录神经症患者水平扫视的性能

本文介绍了一种实用的方法, 用电子 oculogram 在神经系统患者中记录高准确度的水平眼球运动, 使用一个宽塑料边缘的杯银 AgCl 电极。稳定的测量需要正确的电极选择和固定, 有足够的时间来适应光的发生, 并根据需要重新校准。

Electro-oculogram (EOG) has been widely used for clinical eye movement recording, especially horizontal saccades, although the video-oculography (VOG) has ...

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Automated Visual Cognitive Tasks for Recording Neural Activity Using a Floor Projection Maze

使用地面投影迷宫自动化视觉认知任务记录神经活动

Neuropsychological tasks used in primates to investigate mechanisms of learning and memory are typically visually guided cognitive tasks. We have ...

Recording Mouse Ultrasonic Vocalizations to Evaluate Social Communication

录制鼠标超声波发声评价社会交往

Mice emit ultrasonic vocalizations in different contexts throughout development and in adulthood. These vocal signals are now currently used as proxies ...

Implantation and Recording of Wireless Electroretinogram and Visual Evoked Potential in Conscious Rats

植入和无线电图记录和视觉诱发电位清醒大鼠

The full-field electroretinogram (ERG) and visual evoked potential (VEP) are useful tools to assess retinal and visual pathway integrity in both ...

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis

眼跟踪控制，以评估患者的认知功能与肌萎缩性脊髓侧索硬化症

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with pathological involvement of upper and lower motoneurons, subsequently leading to ...

A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats

A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats

用于体内的无线双向接口记录和刺激自由行为大鼠的神经活动

In vivo electrophysiology is a powerful technique to investigate the relationship between brain activity and behavior at a millisecond and micrometer ...

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

多列铅脊髓刺激术后腰痛的治疗

Failed back surgery syndrome (FBSS) refers to persistent, chronic pain following spinal surgery. Spinal cord stimulation with dorsal epidural leads can be ...

Using Electroencephalography Measurements and High-quality Video Recording for Analyzing Visual Perception of Media Content

利用脑电图测量和高质量视频记录分析媒体内容的视觉感知

This article explores a method to detect differences in visual perception in humans. The method used is based on the psychological (or "cognitive") ...

Simultaneous Eye Tracking and Single-Neuron Recordings in Human Epilepsy Patients

人类癫痫患者同步眼动追踪和单神经记录

Intracranial recordings from patients with intractable epilepsy provide a unique opportunity to study the activity of individual human neurons during ...

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

稳定慢性阻塞性肺病患者家庭处方肺运动

As a systemic disease, chronic obstructive pulmonary disease (COPD) affects the respiratory system, inducing restless and exercise dyspnea. It also ...