Name: the application of 1% methylene blue dye as a single technique in breast cancer sentinel node biopsy
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İnsan konuları da dahil olmak üzere tüm prosedürler, 040/KEPK/VII/2017 sertifika numarası ile Dharmais Kanser Hastanesi Etik Komitesi tarafından onaylanmıştır. Tüm hastalar onay formlarını imzaladılar ve bu araştırmaya katılmak için anlaşma ifade etti.
Not: ekleme kriterleri erken meme kanseri tanısı olan hastalarda, tümör aşaması T1-T2 ile palpe ve ultrasonografi lenf nodları genişlemesi (cNo). Dışlama kriterleri yerel olarak gelişmiş meme kanseri, Neo adjuvan k...

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	<li>Giuliano, A. E., Han, S. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Local+and+regional+control+in+breast+cancer:+role+of+sentinel+node+biopsy.">Local and regional control in breast cancer: role of sentinel node biopsy.</a> Advances in Surgery. 45 (1), 101-116 (2011).</li><li>D'Angelo-Donovan, D. D., Dickson-Witmer, D., Petrelli, N. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Sentinel+lymph+node+biopsy+in+breast+cancer:+a+history+and+current+clinical+recommendations.">Sentinel lymph node biopsy in breast cancer: a history and current clinical recommendations.</a> Surgical Oncology. 21 (3), 196-200 (2012).</li><li>McLaughlin, S. 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P. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Methylene+blue+dye+as+an+alternative+to+isosulfan+blue+dye+for+sentinel+lymph+node+localization.">Methylene blue dye as an alternative to isosulfan blue dye for sentinel lymph node localization.</a> The Breast Journal. 7 (3), 181-183 (2001).</li><li>Nour, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Efficacy+of+methylene+blue+dye+in+localization+of+sentinel+lymph+node+in+breast+cancer+patients.">Efficacy of methylene blue dye in localization of sentinel lymph node in breast cancer patients.</a> Breast Journal. 10 (5), 388-391 (2004).</li><li>Varghese, P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Methylene+blue+dye+versus+combined+dye-radioactive+tracer+technique+for+sentinel+lymph+node+localisation+in+early+breast+cancer.">Methylene blue dye versus combined dye-radioactive tracer technique for sentinel lymph node localisation in early breast cancer.</a> European Journal of Surgical Oncology. 33 (2), 147-152 (2007).</li><li>Bakhtiar, N., Jaleel, F., Moosa, F. A., Qureshi, N. A., Jawaid, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Sentinel+lymph+node+identification+by+blue+dye+in+patients+with+breast+carcinoma.">Sentinel lymph node identification by blue dye in patients with breast carcinoma.</a> Pakistan Journal of Medical Sciences. 32 (2), 448 (2016).</li><li>Thevarajah, S., Huston, T. L., Simmons, R. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+comparison+of+the+adverse+reactions+associated+with+isosulfan+blue+versus+methylene+blue+dye+in+sentinel+lymph+node+biopsy+for+breast+cancer.">A comparison of the adverse reactions associated with isosulfan blue versus methylene blue dye in sentinel lymph node biopsy for breast cancer.</a> American Journal of Surgical. 189 (2), 236-239 (2005).</li><li>Brahma, B., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+predictive+value+of+methylene+blue+dye+as+a+single+technique+in+breast+cancer+sentinel+node+biopsy:+a+study+from+Dharmais+Cancer+Hospital.">The predictive value of methylene blue dye as a single technique in breast cancer sentinel node biopsy: a study from Dharmais Cancer Hospital.</a> World journal of Surgical Oncology. 15 (1), 41 (2017).</li><li>Lyman, G. H., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Sentinel+lymph+node+biopsy+for+patients+with+early-stage+breast+cancer:+American+society+of+clinical+oncology+clinical+practice+guideline+update.">Sentinel lymph node biopsy for patients with early-stage breast cancer: American society of clinical oncology clinical practice guideline update.</a> Journal of Clinical Oncology. 32 (13), 1365-1383 (2014).</li><li>Mamounas, E. P., Kuehn, T., Rutgers, E. J., von Minckwitz, G. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Current+approach+of+the+axilla+in+patients+with+early-stage+breast+cancer.">Current approach of the axilla in patients with early-stage breast cancer.</a> Lancet. , (2014).</li><li>Peek, M. C., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Is+blue+dye+still+required+during+sentinel+lymph+node+biopsy+for+breast+cancer?.">Is blue dye still required during sentinel lymph node biopsy for breast cancer?.</a> Ecancermedicalscience. , (2016).</li><li>Lyman, G. H., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=American+Society+of+Clinical+Oncology+Guideline+Recommendations+for+Sentinel+Lymph+Node+Biopsy+in+Early-Stage+Breast+Cancer.">American Society of Clinical Oncology Guideline Recommendations for Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer.</a> Journal of Clinical Oncology. 23 (30), 7703-7720 (2005).</li><li>Masannat, Y., Shenoy, H., Speirs, V., Hanby, A., Horgan, K. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Properties+and+characteristics+of+the+dyes+injected+to+assist+axillary+sentinel+node+localization+in+breast+surgery.">Properties and characteristics of the dyes injected to assist axillary sentinel node localization in breast surgery.</a> EJSO. 32 (4), 381-384 (2006).</li><li>Brahma, B., Haryono, S. J., Ramadhan, ., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Methylene+blue+dye+as+a+single+agent+in+breast+cancer+sentinel+lymph+node+biopsy:+initial+study+of+cancer+centre+hospital.">Methylene blue dye as a single agent in breast cancer sentinel lymph node biopsy: initial study of cancer centre hospital.</a> 19th Asian Congress of Surgery &amp; SingHealth Surgical Congress. , (2013).</li><li>Borgstein, P. J., Meijer, S., Pijpers, R. J., van Diest, P. 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I. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Historical+Review+of+Breast+Lymphatic+Studies.">Historical Review of Breast Lymphatic Studies.</a> Clinical Anatomy. 22 (5), 531-536 (2009).</li><li>Sadeghi, R., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Axillary+concordance+between+superficial+and+deep+sentinel+node+mapping+material+injections+in+breast+cancer+patients:+systematic+review+and+meta-analysis+of+the+literature.">Axillary concordance between superficial and deep sentinel node mapping material injections in breast cancer patients: systematic review and meta-analysis of the literature.</a> Breast Cancer Research and Treatment. 144 (2), 213-222 (2014).</li><li>Clough, K. B., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=New+anatomical+classification+of+the+axilla+with+implications+for+sentinel+node+biopsy.">New anatomical classification of the axilla with implications for sentinel node biopsy.</a> British Journal of Surgery. 97 (11), 1659-1665 (2010).</li><li>Ueda, N., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Identification+of+sentinel+lymph+node+location+based+on+body+surface+landmarks+in+early+breast+cancer+patients.">Identification of sentinel lymph node location based on body surface landmarks in early breast cancer patients.</a> Breast Cancer. 16 (3), 219-222 (2009).</li><li>Kang, B., Jun, H., Lee, K., Lee, K., Kim, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Clinical+application+of+sentinel+lymph+node+biopsy+based+on+axillary+anatomy+in+breast+cancer:+A+single+institution+experience.">Clinical application of sentinel lymph node biopsy based on axillary anatomy in breast cancer: A single institution experience.</a> The Breast. 23 (6), 812-815 (2014).</li><li>Layfield, D. M., Agrawal, A., Roche, H., Cutress, R. I. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Intraoperative+assessment+of+sentinel+lymph+nodes+in+breast+cancer.">Intraoperative assessment of sentinel lymph nodes in breast cancer.</a> British Journal of Surgery. 98 (1), 4-17 (2011).</li><li>Weaver, D. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Pathology+evaluation+of+sentinel+lymph+nodes+in+breast+cancer:+protocol+recommendations+and+rationale.">Pathology evaluation of sentinel lymph nodes in breast cancer: protocol recommendations and rationale.</a> Modern Pathology. 23 (S2), S26 (2010).</li><li>Bishop, J. A., Sun, J., Ajkay, N., Sanders, M. A. G. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Decline+in+Frozen+Section+Diagnosis+for+Axillary+Sentinel+Lymph+Nodes+as+a+Result+of+the+American+College+of+Surgeons+Oncology+Group+Z0011+Trial.">Decline in Frozen Section Diagnosis for Axillary Sentinel Lymph Nodes as a Result of the American College of Surgeons Oncology Group Z0011 Trial.</a> Archives of Pathology and Laboratory Medicine. 140 (8), 830-835 (2015).</li><li>Thevarajah, S., Huston, T. L., Simmons, R. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+comparison+of+the+adverse+reactions+associated+with+isosulfan+blue+versus+methylene+blue+dye+in+sentinel+lymph+node+biopsy+for+breast+cancer.">A comparison of the adverse reactions associated with isosulfan blue versus methylene blue dye in sentinel lymph node biopsy for breast cancer.</a> American Journal of Surgery. 189 (2), 236-239 (2005).</li><li>Stradling, B., Aranha, G., Gabram, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Adverse+skin+lesions+after+methylene+blue+injections+for+sentinel+lymph+node+localization.">Adverse skin lesions after methylene blue injections for sentinel lymph node localization.</a> American Journal of Surgery. 184 (4), 350-352 (2002).</li></ol>

Meme kanseri cerrahisi modern çağda, SNB erken meme kanserinde aksiller evreleme için bakım standardı olarak alnd yerini aldı ve SNS metasürden serbest ise alnd terk edilmelidir14,15. Gelişmiş ülkelerde yaygın olarak kullanılan lenfatik haritalama tekniği radioizotope Tracer ve PBD 'nin kombine veya tek bir teknik olarak uygulanması16,17. Nasıl SNB gerçekleştirmek için soru radyoizotope ...

Aksiller lenf nodlarının (ALNs) metastasinin durumu meme kanserinde en önemli prognostik faktördür. Aksiller lenf nodu diseksiyonu (ALND), alns1,2metastatik durumunu değerlendirmek için konvansiyonel prosedürdür. Ne yazık ki, alnd, özellikle bu prosedürün sonra lenfödem riskini artırarak, yaşam kalitesini azaltan hastalara morbidite sonuçları3,4. Günümüzde Sentinel düğüm biyopsisi (SNB) hastaların5' inde minimal morbidite nedeniyle aksiller evreleme IÇIN alnd yerine gelmiştir. SNB gerçekleştirmek için en yaygın yöntem radyoizotop Tracer ve PBD6kullanıyor. Dünyanın bazı bölgelerinde, gelişmekte olan ülkelerde de dahil olmak üzere, bu izleyici ajanları almak zor olabilir ve alternatif bir Tracer Ajan arama sorunu çözmek için önemlidir.
Başlangıçta, MBD tarafından kullanıldı Wong ve al. Sentinel düğümleri haritalama için bir izleyici aracı olarak (SNs)7. Bir kedi modeli kullanarak çalışma, MBD intradermal enjeksiyon kötü lenfatik alımı gösterdi ve izosulfan mavi Sentinel düğüm için tercih edilen boya olarak seçildi (sn) haritalama7. Metilen mavi boya, Simmons ve ark.8' in ilk başarılı raporu beri meme kanseri SNB kullanılmıştır. Çeşitli çalışmalar da SNS kimlik için olumlu boya olarak MBD bildirdi ve MBD tekniğinin yanlış negatif oranlarının radyoizotop veya PBD9,10,11ile karşılaştırılabilir olduğunu. Daha az alerjik reaksiyonlar ve düşük fiyat SN haritalama12kullanımını dikkate almak için diğer nedenler vardır.
Son zamanlarda, klinik düğüm negatif meme kanseri SNB için tek başına 1% MBD kullanımı okudu. Erken aşamalarında, MBD olumlu bir kimlik oranı ve negatif tahmin değeri13vardır. Biz enjekte 2 ml% 1 MBD subareolar alanı veya peritümöral alana Eğer bir eksizyonel biyopsi yara üst dış dörtgen veya meme areolar kompleksi (NAC) meme. Mavi düğümler ve lenfatik mavi kanallar ile mavi olmayan düğümler SNs olarak sınıflandırılır. Aksilla 'daki anatomik dönüm noktası, SNS 'i bulmak için bir rehberlik olarak kullanılır. metastaz değerlendirilmesi için intraoperatif muayene uygulanır ve Amerikan klinik Onkoloji Derneği (Asco) kurallar14' e dayanan histopatoloji analizi için sn 'ler gönderilir.
Durumlarda dikkatle seçilir ve bu tekniği için gerekli becerileri cerrahlar yanı sıra patologlar tarafından elde edilir, birçok hasta hala olumlu hayatta kalırken ALND zararlı etkilerinden kurtarılabilir.

<table border="0" cellpadding="0" cellspacing="0" style="width:1046px;" width="1046">
	<tbody>
		<tr height="40">
			<td height="40" style="height:40px;width:348px;">Metiblo 50mg/5ml</td>
			<td style="width:174px;">Laboratories Sterop NV</td>
			<td style="width:353px;">BE475217</td>
			<td style="width:171px;">Methylene Blue Dye</td>
		</tr>
		<tr height="40">
			<td height="40" style="height:40px;">Disposable syringe with needle - 3mL (Luer Lock Tip)</td>
			<td>Terumo Europe NV</td>
			<td>dvr-3414</td>
			<td>Syringe for Injection</td>
		</tr>
		<tr height="40">
			<td height="40" style="height:40px;">ForceTriad energy platform</td>
			<td>Medtronic</td>
			<td>ForceTriad</td>
			<td>Surgical cautery</td>
		</tr>
		<tr height="40">
			<td height="40" style="height:40px;">Shandon Cryomatrix embedding resin</td>
			<td>Thermo (scientific)</td>
			<td>6769006</td>
			<td rowspan="2">Frozen Section</td>
		</tr>
		<tr height="40">
			<td height="40" style="height:40px;">Cryotome FSE</td>
			<td>Thermo (scientific)</td>
			<td>77210153</td>
		</tr>
		<tr height="40">
			<td height="40" style="height:40px;">HistoStar Embedding Workstation</td>
			<td>Thermo (scientific)</td>
			<td>A81000001</td>
			<td rowspan="3" style="width:171px;">Histopathological Examination</td>
		</tr>
		<tr height="40">
			<td height="40" style="height:40px;">Finesse Me+</td>
			<td>Thermo (scientific)</td>
			<td>A77510272</td>
		</tr>
		<tr height="40">
			<td height="40" style="height:40px;">Gemini AS</td>
			<td>Thermo (scientific)</td>
			<td>A81500002</td>
		</tr>
		<tr height="40">
			<td height="40" style="height:40px;">Benchmark GX</td>
			<td>Ventana Medical Systems</td>
			<td>750-850</td>
			<td rowspan="2">Immunohistochemistry</td>
		</tr>
		<tr height="40">
			<td height="40" style="height:40px;">Benchmark XT</td>
			<td>Ventana Medical Systems</td>
			<td>750-700</td>
		</tr>
		<tr height="40">
			<td height="40" style="height:40px;">Microscope</td>
			<td>Olympus</td>
			<td>Model BX53</td>
			<td></td>
		</tr>
		<tr height="40">
			<td height="40" style="height:40px;">Ultrasound</td>
			<td>Phillips</td>
			<td>HD 7XE</td>
			<td></td>
		</tr>
	</tbody>
</table>

the application of 1% methylene blue dye as a single technique in breast cancer sentinel node biopsy

Bu çalışmada, meme subareolar veya peritümöral uzaya% 1 metilen mavi boya (MBD) enjekte ettik. Meme koruyucu cerrahi (BCS) durumunda, Sentinel nodları (SNs) bulmak için alt aksiyilla saç çizgisinde ayrı bir kesi yapılmıştır. Mastektomi sırasında, SNs aynı mastektomi kesi ile tespit edildi. SNs mavi düğümleri veya lenfatik mavi kanallar ile düğümler olarak tanımlanmıştır. SNs kimliğini kolaylaştırmak için akilla içinde anatomik bir dönüm noktası kullanılmıştır. SNs metastaz, intraoperatif dondurulmuş bölüm Analizi ve histopatoloji muayenesi ile altın standart olarak değerlendirildi. Burada, MBD 'yi, radyoizotop Tracer veya patent veya izosulfan mavi boya (PBD) sağlanamazsa yararlı olabilecek meme kanseri Sentinel düğüm biyopsisi (SNB) içinde yalnız tekniği olarak nitelendirdik.

Burada, sunulan tekniğin sonuçlarını tarif ediyoruz. İki mililitre 1% MBD enjeksiyon standart tekniği olarak derin subareolar uzayda enjekte edildi (Şekil 1a). Peritümöral enjeksiyon endikedir, ultrason rehberlik altında yapılmalıdır (Şekil 1B). Aksiller uzaya girdikten sonra mavi düğümler veya lenfatik mavi yollar görüldü. Lenfatik mavi yolları takiben SNs bulma yol (Şekil 2a)....

Watch this Scientific Journal Video about The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy at JoVE.com

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy (Video) | JoVE

Endonezya 'da, radyoizotop Tracer ve izosulfan veya patent mavi boya (PBD) sağlamak için kısıtlama nedeniyle Sentinel düğüm biyopsisi (SNB) meme kanseri cerrahisi için rutin olarak yapılmaz. Bu engeli aşmak için Sentinel nodları (SNs) eşlemek için tek bir ajan olarak% 1 metilen mavi boya (MBD) uygulandımız.

Meme kanseri Sentinel düğüm biyopsi tek bir tekniği olarak 1% metilen mavi boya uygulaması

In this study, we injected 1% methylene blue dye (MBD) into the subareolar or peritumoral space of the breast. In the case of breast conserving surgery ...

Meme kanseri sentinel düğüm biyopsisinde tek bir teknik olarak yüzde bir metilen mavisi boya uygulaması. Bu işlemin genel amacı, erken meme kanseri aksiller düğüm biyopsisi için tek bir teknik olarak tek başına mavi boya uygulamasını göstermek, %1 metilen mavi boya kullanarak sentinel düğümlerin izosulfan incelemesinin nasıl yapılacağını göstermektir. Yüzde bir metilen maviboya ve enjeksiyon tekniği Bölüm bir hazırlık.Meme koruyucu cerrahide bölüm iki sentinel nod biyopsi tekniği. Üçüncü bölüm. mastektomide sentinel nod biyopsi tekniği.Sentinel düğümlerin dördüncü bölümünde patolojik inceleme. Bölüm 5 intraoperatif muayene. Altıncı bölüm sonuçları.Bölüm 7 sonuç.

Research

JoVE Journal

Cancer Research

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures (Video) | JoVE

İşlevsel Genomik Tarama kullanılması Kanser Hücre Sfero Kültürleri Potansiyel Yeni İlaç Hedefleri Belirlemek İçin

The identification of functional driver events in cancer is central to furthering our understanding of cancer biology and indispensable for the discovery ...

Ultrasonographic Evaluation of Breast Cancer-related Lymphedema

Ultrasonographic Evaluation of Breast Cancer-related Lymphedema (Video) | JoVE

Meme Kanseri ile ilgili Lenfödem Ultrasonografik Olarak Değerlendirilmesi

Lymphedema is one of the most common complications after breast cancer surgery. There are many diagnostic tools for lymphedema, but no standard method yet ...

Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells

Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells (Video) | JoVE

Lazer mikro-ile kullanma için tek incelenmesi ve çift Strand Break onarım memeli hücrelerinde

Highly coordinated DNA repair pathways exist to detect, excise and replace damaged DNA bases, and coordinate repair of DNA strand breaks. While molecular ...

Flow Cytometric Detection of Newly-formed Breast Cancer Stem Cell-like Cells After Apoptosis Reversal

Flow Cytometric Detection of Newly-formed Breast Cancer Stem Cell-like Cells After Apoptosis Reversal (Video) | JoVE

Apoptozis ters sonra yeni kurulan meme kanser kök hücre benzeri hücre akış sitometrik algılama

Cancer recurrence has long been studied by oncologists while the underlying mechanisms remain unclear. Recently, we and others found that a phenomenon ...

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model (Video) | JoVE

Ortotopik Meme Kanseri Modeli Kullanarak Üçlü Negatif Meme Kanseri Eğitimi

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited therapeutic options. When compared to patients with less ...

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer (Video) | JoVE

Meme Kanseri için Preklinik Modeller Olarak Meme Tümörlerinin Ortopedik Transplantasyonu

Preclinical models that faithfully recapitulate tumor heterogeneity and therapeutic response are critical for translational breast cancer research. ...

Using Computer-based Image Analysis to Improve Quantification of Lung Metastasis in the 4T1 Breast Cancer Model

Using Computer-based Image Analysis to Improve Quantification of Lung Metastasis in the 4T1 Breast Cancer Model (Video) | JoVE

4T1 Meme Kanseri Modelinde Akciğer Metastazının Nicelleştirilmesini Geliştirmek Için Bilgisayar Tabanlı Görüntü Analizinin Kullanılması

Breast cancer is a devastating malignancy, accounting for 40,000 female deaths and 30% of new female cancer diagnoses in the United States in 2019 alone. ...

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System (Video) | JoVE

Mikrofizyolojik Sistem Kullanarak İnsan Meme Dokusunda Meme Kanseri Modellemesi

Breast cancer (BC) remains a leading cause of death for women. Despite more than $700 million invested in BC research annually, 97% of candidate BC drugs ...

Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells

Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells (Video) | JoVE

İnflamatuar Meme Kanseri Hücrelerinin Kuyruk-Ven Enjeksiyonu ile Beyin Metastazının Modellenmesi

Metastatic spread to the brain is a common and devastating manifestation of many types of cancer. In the United States alone, about 200,000 patients are ...

Mammary Epithelial and Endothelial Cell Spheroids as a Potential Functional In vitro Model for Breast Cancer Research

Mammary Epithelial and Endothelial Cell Spheroids as a Potential Functional In vitro Model for Breast Cancer Research (Video) | JoVE

Meme Kanseri Araştırmaları için Potansiyel Fonksiyonel In vitro Model Olarak Meme Epitel ve Endotel Hücre Sferoidleri

Breast cancer is the leading cause of mortality in women. The growth of breast cancer cells and their subsequent metastasis is a key factor for its ...