Identifying Synergy Prediction Mutants from Chemical-genetics Dataset by the Overlap2 Method
1:17
Validation of Predicted Synergistic Interactions
4:52
High-throughput Screen with Synergy Prediction Mutants to Identify the Novel Synergistic Pairs
5:21
Results: Use of Checkerboard Assay to Identify and Validate Synergistic Drug Molecules
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Conclusion
Transcript
The overall goal of this methodology is to identify the synergistic molecules, which amplify each others activity, when combined through High-throughput screening. Synergistic drug pairs are a promising strategy, for combating drug resistant infec
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Synergistisk rusmiddelkombinasjoner er vanskelig og tidkrevende å identifisere empirisk. Her beskriver vi en metode for å identifisere og validere synergistisk små molekyler.