Name: invasive hemodynamic characterization of the portal-hypertensive syndrome in cirrhotic rats
Uploaded: 2018-08-01T13:00:00
Description: Watch this Scientific Journal Video about Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats at JoVE.com

Bizim araştırma projeleri sırasında veteriner hekimler, hemşireler ve hayvan sahipleri, Merkezi Biyomedikal araştırma sürekli destek için teşekkür ederiz. Yazarlar bu protokolün tüm gözden geçirenlerin önemli giriş kabul eder. Bazı araştırma finanse Avusturyalı Gastroenteroloji Derneği ve Hepatoloji (ÖGGH) PS "Genç Bilim Ödülü" ve "Skoda Ödülü", Avusturya toplum iç hastalıkları için TR tarafından.

Tüm yöntem tanımlamak burada Viyana Tıp Üniversitesi ve Avusturya Bakanlığı Bilim, araştırma ve Ekonomi (BMWFW) Etik Komitesi tarafından onaylanmış olması. Yordamlar bir operasyon odasında aseptik şartlarda gerçekleştirilen veya benzer olmalıdır cerrahi müdahaleler hemodinamik ölçümleri temsil bu yana çalışma alanı temiz. Genellikle, steril koşullarda çalışma önerilir. Bir inhalasyon anestezi, ameliyat odası iş güvenliği için yeterli havalandırma düşünün. Bir saat süre 40-50 mi...

<ol>
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M., Di Matteo, F. M., Pacella, C. M., Sanyal, A. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Invasive+and+non-invasive+techniques+for+detecting+portal+hypertension+and+predicting+variceral+bleeding+in+cirrhosis:+a+review.">Invasive and non-invasive techniques for detecting portal hypertension and predicting variceral bleeding in cirrhosis: a review.</a> Annals of medicine. 46 (1), 8-17 (2014).</li><li>Kumar, A., Sharma, P., Sarin, S. K. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Hepatic+venous+pressure+gradient+measurement:+time+to+learn.">Hepatic venous pressure gradient measurement: time to learn.</a> Indian J Gastroenterol. 27 (2), 74-80 (2008).</li><li>Tsochatzis, E. A., Bosch, J., Burroughs, A. 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C. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Animal+models+of+portal+hypertension.">Animal models of portal hypertension.</a> World Journal of Gastroenterology : WJG. 12 (41), 6577-6584 (2006).</li><li>Reiberger, T., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Sorafenib+attenuates+the+portal+hypertensive+syndrome+in+partial+portal+vein+ligated+rats.">Sorafenib attenuates the portal hypertensive syndrome in partial portal vein ligated rats.</a> Journal of Hepatology. 51 (5), 865-873 (2009).</li><li>Schwabl, P., et al. <a target="_blank" 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S ana sonuç parametresi için portal hipertansif sendromu değerlendirilmesi ve temel siroz şiddetini yansıtır. Matris ifade (Örneğin, fibrozis) ve (nedeniyle hepatik ifade vasoconstrictors artmış ve kavramaları vazodilatör düşmüştür) sinüsoidal vazokonstriksiyona artan IHVR neden olur. Birden çok preklinik11,12,13,14 ve klinik çalışmalar15<s...

PHT patolojik olarak artan kan basıncı hastalarda siroz atardamarında kanama ve asit1gibi ciddi komplikasyonlara neden olabilir portal venöz sistem tanımlı. Süre öncesi hepatik (Örneğin, portal ven trombozu) ve sonrası hepatik (Örneğin, Budd-Chiari sendromu) PHT nadirdir, karaciğer sirozu nedeniyle intrahepatic PHT PHT2en sık nedeni temsil eder.
Karaciğer sirozu PP öncelikle yükseltilmiş IHVR3sonucu olarak artırılır. İleri aşamalarında PHT artmış kardiyak çıkış nedeniyle artan PVBF tarafından ağırlaştırılmış ve sistemik ve splanchnic vasküler direnci azalmıştır — portal hipertansif sendromu4tanımlama. Ohm Kanunu (ΔP = Q * R) IHVR ve kan akışı s5' e ile orantılı olduğunu gösterir. Hastalarda, doğrudan PP riskli ve düzenli olarak gerçekleştirilen ölçümdür; Bunun yerine, hepatik venöz basınç gradyan (HVPG) s6,7dolaylı bir ölçüt olarak kullanılır. HVPG ücretsiz hepatik venöz basıncı (FHVP) hepatik ven8' yerleştirilen bir balon kateter kullanarak ölçülen kamalı hepatik venöz basınç (WHVP), çıkarılarak hesaplanır. Fizyolojik HVPG bir HVPG ≥10 mmHg klinik olarak anlamlı portal hipertansiyon (CSPH) tanımlar ve atardamarında kanama, asit ve hepatik ensefalopati9 gibi PHT ile ilgili komplikasyon riski gösterir iken 1 – 5 mmHg arasında değişmektedir . (Örneğin, HVPG) PP PHT önem, PHT, diğer bileşenler hakkında bilgiler için en uygun parametre olmasına rağmen hyperdynamic dolaşım (HR, harita), önem splanchnic/mezenterik arteryel kan akımı ve IHVR, için önemlidir PHT farklı temel mekanizması kapsamlı bir anlayış elde edilir.
Böylece, insanlarda dolaylı ölçümleri PP aksine fareler için tanıtılan metodoloji PP doğrudan bir ölçü avantajı sunuyor ve portal hipertansif sendromu karakterize ek Hemodinamik parametreler kayıt sağlayan. Ayrıca, PP doğrudan ölçülmesi karaciğer fibrozis (IHVR önemli bir belirleyici) miktarı mükemmel bir bütünleştirici okuma ve fibrozis miktar için karaciğer dokusu örnekleme hataları ile ilgili bazı sınırlamalar üstesinden gelir.
Cerrahi safra kanalı ligasyonu (BDL), toksin kaynaklı karaciğer hasarı (yani, karbon tetraklorür, thioacetamide veya nitrozamin yönetim tarafından) ve diyet kaynaklı metabolik karaciğer sirozlu PHT en sık kullanılan kemirgen modelleri içerir hastalık modelleri. Prehepatik (sirozlu olmayan) PHT kısmi portal ven ligasyonu (PPVL)10tarafından indüklenen.
Küçük kemirgen fareler, hamster, fare veya tavşan, gibi sunulan yöntem için uygundur ve nispeten düşük bakım maliyeti ile ilişkilidir. Buna rağmen tüm hemodinamik değerlendirmelerinin fareler, daha iyi doğruluk ve tekrarlanabilirlik sonuçlarının gerçekleştirmek için uygun fareler veya daha büyük kemirgen hayvan boyutu bariz avantajı nedeniyle görülür. Buna ek olarak, belirli mikro- ve aygıtlar benzer Hemodinamik parametreler farelerde elde etmek için ihtiyaç vardır. Son olarak, fareler alt ilişkili morbidite ve mortalite ile daha sağlam ve böylece, bırakma oranları farelerde sıçanlarda düşük olasılığı daha yüksektir.
Sunulan metodoloji (yani, anti-fibrotik veya anti-inflamatuar ilaçlar) karaciğer hastalığının spesifik tedaviler değerlendirmek için çok uygundur veya bu etki vasküler sesi ve/veya endotel biyoloji roman farmakolojik yaklaşımlar; ve böylece, PHT olası etkisi Hemodinamik parametreler.

<table>
	<tbody>
		<tr>
			<td>Instruments</td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>LabChart 7 Pro software</td>
			<td>ADInstruments, Colorado Springs, CO, USA</td>
			<td>&#160;-</td>
			<td>Software</td>
		</tr>
		<tr>
			<td>ML870 PowerLab 8/30</td>
			<td>ADInstruments, Colorado Springs, CO, USA</td>
			<td>&#160;-</td>
			<td>Electronic multichannel recorder</td>
		</tr>
		<tr>
			<td>MLT0380/D</td>
			<td>ADInstruments, Colorado Springs, CO, USA</td>
			<td>&#160;-</td>
			<td>Pressure transducer (x2: for Portal Pressure and Arterial Pressure)</td>
		</tr>
		<tr>
			<td>ML112 Quad Bridge Amplifier</td>
			<td>ADInstruments, Colorado Springs, CO, USA</td>
			<td>&#160;-</td>
			<td>Bridge amplifier</td>
		</tr>
		<tr>
			<td>TS420</td>
			<td>Transonic Systems Inc., Ithaca, NY, USA</td>
			<td>&#160;-</td>
			<td>Flowmeter module</td>
		</tr>
		<tr>
			<td>Biological Research Apparatus 7025</td>
			<td>UGO BASILE S.R.L., Comerio, Italy</td>
			<td>&#160;-</td>
			<td>Ventilator</td>
		</tr>
		<tr>
			<td>Vapor 2000</td>
			<td>Dr&#228;ger Medical AG &#38; Co. KG, L&#252;beck, Germany</td>
			<td>&#160;-</td>
			<td>Isofluran Vaporizer</td>
		</tr>
		<tr>
			<td>Perivascular probes (rat) for Transonic systems (Superior Mesenteric Artery)</td>
			<td>Transonic Systems Inc., Ithaca, NY, USA</td>
			<td>#MA1PRB</td>
			<td>Ultrasonic flow probe (1mm)</td>
		</tr>
		<tr>
			<td>Perivascular probes (rat) for Transonic systems (Portal Vein)</td>
			<td>Transonic Systems Inc., Ithaca, NY, USA</td>
			<td>#MA2PSB</td>
			<td>Ultrasonic flow probe (2mm)</td>
		</tr>
		<tr>
			<td>1st for intubation &#38; 2nd for clean skin incisions</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
			<td>Mayo scissor [x2]</td>
		</tr>
		<tr>
			<td>Metzenbaum scissor</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
		</tr>
		<tr>
			<td>Cuticle scissor</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
		</tr>
		<tr>
			<td>e.g. Adson Brown tissue forceps</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
			<td>Tissue Forceps</td>
		</tr>
		<tr>
			<td>High precision 45&#176; angle broad point forceps [x2]</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
		</tr>
		<tr>
			<td>Hemostat [x4]</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
		</tr>
		<tr>
			<td>e.g. Mikulicz peritoneal clamp</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
			<td>Curved clamp</td>
		</tr>
		<tr>
			<td>e.g. Dieffenbach clamp</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
			<td>Micro clamp</td>
		</tr>
		<tr>
			<td>e.g. micro spatula with flat ends, width 4 mm,</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
			<td>Micro metal spatula</td>
		</tr>
		<tr>
			<td>for transbuccal suture at intubation</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
			<td>Needle holder</td>
		</tr>
		<tr>
			<td>Scalpel grip</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
		</tr>
		<tr>
			<td>selfmade</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
			<td>Intubation desk</td>
		</tr>
		<tr>
			<td>blut, flexible and with a suitable diameter for arterial cannula and venflow</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
			<td>Blunt steel wire</td>
		</tr>
		<tr>
			<td>modified arterial line 20G with Flowstich</td>
			<td>Becton Dickinson, Farady Road, Swindon, UK</td>
			<td>#682245</td>
			<td>Arterial line</td>
		</tr>
		<tr>
			<td>Heating pad</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
		</tr>
		<tr>
			<td>Rectal temerature probe</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
		</tr>
		<tr>
			<td>Saline heater</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
		</tr>
		<tr>
			<td>Laryngoscope (specific for animal size, e.g. rat)</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
		</tr>
		<tr>
			<td>Inductionbox for inhalation anesthesia</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
		</tr>
		<tr>
			<td>Scale (able to measure mg)</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
		</tr>
		<tr>
			<td>Hair clipper</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
			<td>&#160;-</td>
		</tr>
		<tr>
			<td>Name </td>
			<td>Company </td>
			<td>Catalog Number</td>
			<td>Comments</td>
		</tr>
		<tr>
			<td>Consumables </td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>e.g. modified BD Venflon Pro Safety 14GA</td>
			<td>Becton Dickinson Infusion Therapy, AB, SE251 06 Helsingborg, Sweden</td>
			<td>#393230</td>
			<td>Peripheral venous catheter (14G)</td>
		</tr>
		<tr>
			<td>Fine-Bore Polyethylene Tubing, ID 0.58mm, OD 0.96mm, Portex,</td>
			<td>Smiths Medical International Ltd., Kent, UK</td>
			<td>#800/100/200</td>
			<td>Catheter tube (PE-50)</td>
		</tr>
		<tr>
			<td>e.g. Omnifix-F Solo</td>
			<td>B. Braun Melsungen AG, Melsungen, Germany</td>
			<td>#9161406V</td>
			<td>Syringe 1mL</td>
		</tr>
		<tr>
			<td>e.g. Injekt Solo</td>
			<td>B. Braun Melsungen AG, Melsungen, Germany</td>
			<td>#4606051V</td>
			<td>Syringe 5mL</td>
		</tr>
		<tr>
			<td>e.g. Injekt Solo</td>
			<td>B. Braun Melsungen AG, Melsungen, Germany</td>
			<td>#4606205V</td>
			<td>Syringe 20mL</td>
		</tr>
		<tr>
			<td>e.g. BD Microlance 3, 18G - 1 1/2&#34;</td>
			<td>Becton Dickinson S.A., Fraga, Spain</td>
			<td>#304622</td>
			<td>Cannula (18G)</td>
		</tr>
		<tr>
			<td>e.g. BD Microlance 3, 23G - 1&#34;</td>
			<td>Becton Dickinson S.A., Fraga, Spain</td>
			<td>#300800</td>
			<td>Cannula (23G)</td>
		</tr>
		<tr>
			<td>e.g. BD Microlance 3, 30G - 1/2&#34;</td>
			<td>Becton Dickinson S.A., Fraga, Spain</td>
			<td>#304000</td>
			<td>Cannula (30G) </td>
		</tr>
		<tr>
			<td>e.g. Leukoplast S</td>
			<td>BSN medical GmbH, Hamburg,&#160; Germany</td>
			<td>#47619-00</td>
			<td>Adhesive tape</td>
		</tr>
		<tr>
			<td>e.g. Gazin RK Mullkompressen (18x8cm)</td>
			<td>Lohmann &#38; Rauscher, Vienna, Austria</td>
			<td>#10972</td>
			<td>Gauze compress (small)</td>
		</tr>
		<tr>
			<td>e.g. Gazin RK Mullkompressen (5x5cm)</td>
			<td>Lohmann &#38; Rauscher, Vienna, Austria</td>
			<td>#10961</td>
			<td>Gauze compress (big)</td>
		</tr>
		<tr>
			<td>Silk Braided black, USP 4/0, EP 1.5</td>
			<td>SMI AG, St. Vith, Belgium</td>
			<td>#2021-04</td>
			<td>Suture (Silk 4/0, EP 1.5)</td>
		</tr>
		<tr>
			<td>e.g. Mersilk, 2-0 (3 Ph. Eur.), PS-1 Prime</td>
			<td>Johnson &#38; Johnson Medical GmbH - Ethicon Deutschland, Germany</td>
			<td>#EH7552</td>
			<td>Transbuccal suture</td>
		</tr>
		<tr>
			<td>e.g. Cottonbuds (2.2mm, 15cm)</td>
			<td>Paul Hartmann AG, Heidenheim, Germany</td>
			<td>#967936</td>
			<td>Cotton buds</td>
		</tr>
		<tr>
			<td>e.g. Vue Ultrasoundgel</td>
			<td>Optimum Medical Limited, UK</td>
			<td>#1157</td>
			<td>Ultrasound gel</td>
		</tr>
		<tr>
			<td>e.g. Glubran 2</td>
			<td>Gem srl, Viareggio, Italy</td>
			<td>#G-NB2-50</td>
			<td>Tissue glue</td>
		</tr>
		<tr>
			<td>e.g. Surgical scalpell knife Nr. 10 - carbon steel</td>
			<td>Swann-Morton, England, B.S.</td>
			<td>#202</td>
			<td>Scalpel Knife</td>
		</tr>
		<tr>
			<td>Heparin, 5000 i.E./mL (Natriumheparin)</td>
			<td>Medicamentum Pharma GmbH, Allerheiligen im M&#252;rztal, Austria</td>
			<td>&#160;-</td>
			<td>Heparin</td>
		</tr>
		<tr>
			<td>Florane</td>
			<td>Aesica Queenborough Ltd., Queenborough, UK</td>
			<td>&#160;-</td>
			<td>Isoflurane</td>
		</tr>
		<tr>
			<td>OeloVital (5g)</td>
			<td>Fresenius Kabi Austira Gmbh, Graz, Austria</td>
			<td>&#160;-</td>
			<td>Eye gel</td>
		</tr>
		<tr>
			<td>Ketasol</td>
			<td>aniMedica GmbH, Senden-B&#246;sensell, Germany</td>
			<td>&#160;-</td>
			<td>Ketamine</td>
		</tr>
		<tr>
			<td>Rompun</td>
			<td>Bayer Austria Ges.m.b.H., Vienna, Austria</td>
			<td>&#160;-</td>
			<td>Xylazine</td>
		</tr>
		<tr>
			<td>Xylocain 10% Pumpspray</td>
			<td>AstraZeneca &#214;sterreich GmbH, Vienna, Austria</td>
			<td>&#160;-</td>
			<td>Lidocaine pump spray</td>
		</tr>
		<tr>
			<td>Dipidolor</td>
			<td>Jansen-Cilag Pharma GmbH, Vienna, Austria</td>
			<td>&#160;-</td>
			<td>Piritramide</td>
		</tr>
		<tr>
			<td>NaCl 0.9% Fresenius, 1L</td>
			<td>Fresenius Kabi Austira GmbH, Graz, Austria</td>
			<td>#13LIP132</td>
			<td>Physiological saline solution</td>
		</tr>
	</tbody>
</table>

invasive hemodynamic characterization of the portal-hypertensive syndrome in cirrhotic rats

Bu portal hipertansif sendromu karakterizasyonu için sirozlu fareleri invaziv hemodinamik ölçümlerde açıklayan ayrıntılı bir protokoldür. Portal hipertansiyon (PHT) siroz nedeniyle karaciğer hastalığı olan hastalarda en ciddi komplikasyonlar sorumludur. Portal hipertansif sendromu tam resim artan intrahepatic vasküler direnç (IHVR), hyperdynamic dolaşımı ve artmış splanchnic kan akımı nedeniyle artan portal basıncı (PP) ile karakterizedir. İlerici splanchnic arteriyel vazodilatasyon ve artmış kardiyak çıktı yüksek kalp hızı (HR) ama düşük arteriyel basınç ile karakterize portal hipertansif sendromu.
Roman terapiler PP azaltmak için bu amaçla tarafından hedefleme ya IHVR Şu anda geliştirilmekte olan veya splanchnic kan akımı artmış — ama yan etkileri üzerinde sistemik hemodinami oluşabilir. Böylece, portal venöz, splanchnic ve sistemik Hemodinamik parametreler detaylı karakterizasyonu, ölçüm PP, portal venöz kan akımı (PVBF), mezenterik arteryel kan akımı, ortalama arter basıncı (Harita) ve insan kaynakları da dahil olmak üzere için gereklidir preklinik PHT için yeni tedavi etkinliğinin değerlendirilmesi. Video makalemizi sirozlu fareleri invaziv hemodinamik ölçümleri gerçekleştirmek için yapılandırılmış bir protokol ile okuyucu sağlar. Özellikle, biz femoral arter ve portal ven yoluyla bir ileocolic ven kateterizasyonu ve portal venöz ölçümü tarif ve splanchnic kan akımı perivasküler Doppler ultrason akışı probları ile. Farklı fare modelleri PHT temsilcisi sonuçları gösterilir.

Hayvan modeli ve karaciğer hastalığı şiddetine bağlı olarak, PHT derecesini ve portal hipertansif sendromu şiddeti farklı (Şekil 7) olduğunu.
BDL modeli biliyer siroz nedeniyle Histiositoz neden olur. Buna göre zaman ve bir hyperdynamic üzerinde s artırır dolaşım geliştirir, İK artış ve harita azalma görüldüğü gibi. Sirozlu hayvanlarda, SMABF, PVBF ve IHVR da önemlisi hepa...

Watch this Scientific Journal Video about Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats at JoVE.com

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Burada portal hipertansif sendromu sıçanlarda karakterize için portal basınç, splanchnic kan akımı ve sistemik hemodinami gibi hemodinamik parametrelerin invaziv ölçümleri için detaylı bir protokol açıklayın.

Sirozlu fareleri Portal hipertansif sendromunda invaziv hemodinamik karakterizasyonu

This is a detailed protocol describing invasive hemodynamic measurements in cirrhotic rats for the characterization of portal hypertensive syndrome. ...

Research

JoVE Journal

Medicine

Monitoring of Systemic and Hepatic Hemodynamic Parameters in Mice

Farelerde Sistemik ve Karaciğer Hemodinamik Parametrelerin İzleme

The use of mouse models in experimental research is of enormous importance for the study of hepatic physiology and pathophysiological disturbances. ...

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

Sıçanlarda sonografik Teknoloji Kullanımı İlaç Kaynaklı Böbrek Hemodinamik Bozukluğu Erken Tespiti

The kidney normally functions to maintain hemodynamic homeostasis and is a major site of damage caused by drug toxicity. Drug-induced nephrotoxicity is ...

Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension

Pulmoner Hipertansiyon Kemirgen Modeller Hemodinamik Karakterizasyonu

Pulmonary arterial hypertension (PAH) is a rare disease of the pulmonary vasculature characterized by endothelial cell apoptosis, smooth muscle ...

Minimally Invasive Transverse Aortic Constriction in Mice

Farelerde Minimal İnvaziv Enine Aort Konstrüksiyon

Minimally invasive transverse aortic constriction (MTAC) is a more desirable method for the constriction of the transverse aorta in mice than standard ...

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS

Aort ve pulmoner arter hemodinami ARDS, büyük bir hayvan modeli invaziv hemodinamik izleme

One of the leading causes of morbidity and mortality in patients with heart failure is right ventricular (RV) dysfunction, especially if it is due to ...

Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome

Oleik asit enjeksiyon domuzlarda Akut Respiratuar Distress Sendromu için bir Model olarak

The acute respiratory distress syndrome is a relevant intensive care disease with an incidence ranging between 2.2% and 19% of intensive care unit ...

Simultaneous Electrocardiography Recording and Invasive Blood Pressure Measurement in Rats

Eşzamanlı elektrokardiyografi kayıt ve invaziv kan basınç ölçüm sıçanlarda

For studies related to cardiovascular physiology or pathophysiology, blood pressure (BP) and electrocardiography are basic observational parameters. ...

Invasive Hemodynamic Assessment for the Right Ventricular System and Hypoxia-Induced Pulmonary Arterial Hypertension in Mice

Farelerde Sağ Ventrikül Sistemi ve Hipoksiye Bağlı Pulmoner Arteriyel Hipertansiyon için İnvaziv Hemodinamik Değerlendirme

Pulmonary arterial hypertension (PAH) is a chronic and severe cardiopulmonary disorder. Mice are a popular animal model used to mimic this disease. ...

A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery

Rekonstrüktif Mikrocerrahide İskemi-Reperfüzyon Hasarı Nın İnceleştirilmesinde Klinik Öncesi Sıçan Modeli

Ischemia-reperfusion injury is the main cause of flap failure in reconstructive microsurgery. The rat is the preferred preclinical animal model in many ...

Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System

Sıçanlarda Miyokard İnfarktüsü İndükleyen Yarı-Minimal İnvaziv Yöntem ve İzole Çalışan Kalp Sistemi Ile Kardiyak Fonksiyonun Değerlendirilmesi

Myocardial infarction (MI) remains the main contributor to morbidity and mortality worldwide. Therefore, research on this topic is mandatory. An easily ...