Synthesis of (6R)-1-[(R)-1-Phenylethyl)-1-Azoniabicyclo[4.1.0]Heptane Tosylate
2:49
General Procedure for the Expansion of 1-Azoniabicyclo[4.1.0]Heptane Tosylate
3:53
Synthesis of (S)-1-[(R)-1-Phenylethyl]azepan-3-ol
5:14
Synthesis of [(2R,3R,4R)-3,4-Bis(Benzyloxy)-1-(S)-1-Phenylethyl)Piperidin-2-Yl]Methyl Acetate
8:03
Results: Synthesis and Characterization of Bicyclic Aziridinium Ions and its Ring Expansion to Azaheterocycles
9:53
Conclusion
Transcript
This method can help to answer key questions in the field of bicyclic aziridinium ion chemistry for the synthesis of various various azaheterocycles including bipyridine and azepine ring systems. The main advantage of this technique is that the sy
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Bisyklisk aziridinium ioner som 1-azoniabicyclo [4.1.0] heptane tosylate ble generert fra 2-[4-tolenesulfonyloxybutyl] aziridine, som ble benyttet for utarbeidelse av substituerte piperidines og azepanes via regio- og stereospecific Ring-utvidelse med ulike nucleophiles. Denne svært effektive protokollen tillatt oss å forberede ulike azaheterocycles inkludert naturlige produkter som fagomine, febrifugine analog og balanol.