Differentiation of Li-Fraumeni Syndrome (LFS) Patient-derived Induced Pluripotent Stem Cell (iPSC) to Mesenchymal Stem Cell (MSC) (Days 0 - 28)
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iPSC-derived MSC Maturation (Day 28 - 45) and Differentiation of LFS MSC to Osteoblasts (Day 0 - 24)
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Xenograft In Vivo Tumorigenesis Model Setup
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Results: Representative LFS MSC Differentiation
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Conclusion
Transcript
This Li-Fraumeni syndrome iPSC-based osteosarcoma model can help answer key questions in the osteosarcoma research field about using patient iP cells in cancer modeling. The main advantage of this model is that it allows the generation unlimited c
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Hier presenteren we een protocol voor het genereren van geïnduceerde pluripotente stamcellen (iPSCs) van Li-Fraumeni syndroom (LFS) patiënt afgeleide fibroblasten, differentiatie van iPSCs via mesenchymale stamcellen (MSCs) botcellen te modelleren in vivo tumorigenesis met behulp van LFS patiënt afkomstige botcellen.