Differentiation of Li-Fraumeni Syndrome (LFS) Patient-derived Induced Pluripotent Stem Cell (iPSC) to Mesenchymal Stem Cell (MSC) (Days 0 - 28)
2:19
iPSC-derived MSC Maturation (Day 28 - 45) and Differentiation of LFS MSC to Osteoblasts (Day 0 - 24)
4:33
Xenograft In Vivo Tumorigenesis Model Setup
6:39
Results: Representative LFS MSC Differentiation
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Conclusion
Transcript
This Li-Fraumeni syndrome iPSC-based osteosarcoma model can help answer key questions in the osteosarcoma research field about using patient iP cells in cancer modeling. The main advantage of this model is that it allows the generation unlimited c
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Hier präsentieren wir Ihnen ein Protokoll für die Erzeugung von induzierten pluripotenten Stammzellen (iPSCs) von Li-Fraumeni Syndrom (LFS) Patienten abgeleiteten Fibroblasten, Differenzierung der iPSCs über mesenchymalen Stammzellen (MSCs), Osteoblasten und Modellierung in vivo Tumorgenese mit LFS Patienten abgeleitet Osteoblasten.