Results: Representative Mature RPE Cell Status Validation
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Conclusion
Transcript
This method can help answer key questions in the ion-channel related retinal diseases field about the molecular mechanisms of BEST1 mutations and pathology of bestrophinopathies. The main advantage of this technique is that it circumvents the diff
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Her præsenterer vi en protokol for at differentiere retinale pigment epitel (ÅV) celler fra humane pluripotente stamceller forsynet med patienten-afledte mutationer. De mutante cellelinjer kan anvendes til funktionelle analyser herunder immunoblotting, immunofluorescens og patch klemme. Denne sygdom i parabol fremgangsmåde omgår vanskeligheden ved at opnå indfødte ÅV menneskeceller.