Name: designing cad/cam surgical guides for maxillary reconstruction using an in-house approach
Uploaded: 2018-08-24T13:00:00
Description: Watch this Scientific Journal Video about Designing CAD/CAM Surgical Guides for Maxillary Reconstruction Using an In-house Approach at JoVE.com

This work was partly supported by JSPS KAKENHI Grant Number JP17K11914.

This study was approved by the authors&#39; institutional review board, and written consent forms were completed by all patients.
1. Preparation of Materials
<ol>
	<li>Use a personal computer, computed tomographic (CT) data of facial bone and fibula, conversion software such as InVesalius20, and three-dimensional (3-D) CAD software (e.g., Blender21). 
	NOTE: A maximum thickness of 1 mm slices of CT data is recommended for an accur...

<ol>
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J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Computer-assisted+design+and+rapid+prototype+modeling+in+microvascular+mandible+reconstruction.">Computer-assisted design and rapid prototype modeling in microvascular mandible reconstruction.</a> The Laryngoscope. 123 (3), 597-604 (2013).</li><li>Roser, S. M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+accuracy+of+virtual+surgical+planning+in+free+fibula+mandibular+reconstruction:+Comparison+of+planned+and+final+results.">The accuracy of virtual surgical planning in free fibula mandibular reconstruction: Comparison of planned and final results.</a> Journal of Oral and Maxillofacial Surgery. 68 (11), 2824-2832 (2010).</li><li>Ayoub, N., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Evaluation+of+computer+assisted+mandibular+reconstruction+with+vascularized+iliac+crest+bone+graft+compared+to+conventional+surgery:+A+randomized+prospective+clinical+trial.">Evaluation of computer assisted mandibular reconstruction with vascularized iliac crest bone graft compared to conventional surgery: A randomized prospective clinical trial.</a> Trials. 15, 114 (2014).</li><li>Stirling, C. E., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Simulated+surgery+and+cutting+guides+enhance+spatial+positioning+in+free+fibular+mandibular+reconstruction.">Simulated surgery and cutting guides enhance spatial positioning in free fibular mandibular reconstruction.</a> Microsurgery. 35 (1), 29-33 (2015).</li><li>Schepers, R. H., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Accuracy+of+fibula+reconstruction+using+patient-specific+CAD/CAM+reconstruction+plates+and+dental+implants:+a+new+modality+for+functional+reconstruction+of+mandibular+defects.">Accuracy of fibula reconstruction using patient-specific CAD/CAM reconstruction plates and dental implants: a new modality for functional reconstruction of mandibular defects.</a> Journal of Cranio-Maxillofacial Surgery. 43 (5), 649-657 (2015).</li><li>Tarsitano, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Mandibular+reconstructions+using+computer-aided+design/computer-aided+manufacturing:+a+systematic+review+of+a+defect-based+reconstructive+algorithm.">Mandibular reconstructions using computer-aided design/computer-aided manufacturing: a systematic review of a defect-based reconstructive algorithm.</a> Journal of Cranio-Maxillofacial Surgery. 43 (9), 1785-1791 (2015).</li><li>Wilde, F., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Multicenter+study+on+the+use+of+patient-specific+CAD/CAM+reconstruction+plates+for+mandibular+reconstruction.">Multicenter study on the use of patient-specific CAD/CAM reconstruction plates for mandibular reconstruction.</a> International Journal of Computer Assisted Radiology and Surgery. 10 (12), 2035-2051 (2015).</li><li>Huang, J. W., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Preliminary+clinic+study+on+computer+assisted+mandibular+reconstruction:+the+positive+role+of+surgical+navigation+technique.">Preliminary clinic study on computer assisted mandibular reconstruction: the positive role of surgical navigation technique.</a> Maxillofacial Plastic and Reconstructive Surgery. 37 (1), 20 (2015).</li><li>Numajiri, T., Nakamura, H., Sowa, Y., Nishino, K. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Low-cost+design+and+manufacturing+of+surgical+guides+for+mandibular+reconstruction+using+a+fibula.">Low-cost design and manufacturing of surgical guides for mandibular reconstruction using a fibula.</a> Plastic and Reconstructive Surgery - Global Open. 4 (7), 805 (2016).</li><li>Numajiri, T., Tsujiko, S., Morita, D., Nakamura, H., Sowa, Y. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+fixation+guide+for+the+accurate+insertion+of+fibular+segments+in+mandibular+reconstruction.">A fixation guide for the accurate insertion of fibular segments in mandibular reconstruction.</a> Journal of Plastic, Reconstructive &amp; Aesthetic Surgery. Open. 12 (8), 1-8 (2017).</li><li>Toto, J. M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Improved+operative+efficiency+of+free+fibula+flap+mandible+reconstruction+with+patient+specific,+computer-guided+preoperative+planning.">Improved operative efficiency of free fibula flap mandible reconstruction with patient specific, computer-guided preoperative planning.</a> Head &amp; Neck. 37 (11), 1660-1664 (2015).</li><li>Avraham, T., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Functional+outcomes+of+virtually+planned+free+fibula+flap+reconstruction+of+the+mandible.">Functional outcomes of virtually planned free fibula flap reconstruction of the mandible.</a> Plastic and Reconstructive Surgery. 134 (628), 634 (2014).</li><li>Sieira, G. R., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Surgical+planning+and+microvascular+reconstruction+of+the+mandible+with+a+fibular+flap+using+computer-aided+design,+rapid+prototype+modeling,+and+precontoured+titanium+reconstruction+plates:+A+prospective+study.">Surgical planning and microvascular reconstruction of the mandible with a fibular flap using computer-aided design, rapid prototype modeling, and precontoured titanium reconstruction plates: A prospective study.</a> British Journal of Oral and Maxillofacial Surgery. 53 (1), 49-55 (2015).</li><li>Seruya, M., Fisher, M., Rodriguez, E. D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Computer-assisted+versus+conventional+free+fibula+flap+technique+for+craniofacial+reconstruction:+An+outcomes+comparison.">Computer-assisted versus conventional free fibula flap technique for craniofacial reconstruction: An outcomes comparison.</a> Plastic and Reconstructive Surgery. 132 (5), 1219-1225 (2013).</li><li>Metzler, P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Three-dimensional+virtual+surgery+accuracy+for+free+fibula+mandibular+reconstruction:+Planned+versus+actual+results.">Three-dimensional virtual surgery accuracy for free fibula mandibular reconstruction: Planned versus actual results.</a> Journal of Oral and Maxillofacial Surgery. 72 (12), 2601-2604 (2014).</li><li>Numajiri, T., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Using+an+in-house+approach+to+CAD/CAM+reconstruction+of+the+maxilla.">Using an in-house approach to CAD/CAM reconstruction of the maxilla.</a> Journal of Oral and Maxillofacial Surgery. 76 (6), 1361-1369 (2018).</li><li>Bosc, R., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Mandibular+reconstruction+after+cancer:+An+in-house+approach+to+manufacturing+cutting+guides.">Mandibular reconstruction after cancer: An in-house approach to manufacturing cutting guides.</a> International Journal of Oral and Maxillofacial Surgery. 46 (1), 24-29 (2017).</li><li>Ganry, L., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Three-dimensional+surgical+modeling+with+an+open-source+software+protocol:+Study+of+precision+and+reproducibility+in+mandibular+reconstruction+with+the+fibula+free+flap.">Three-dimensional surgical modeling with an open-source software protocol: Study of precision and reproducibility in mandibular reconstruction with the fibula free flap.</a> International Journal of Oral and Maxillofacial Surgery. 46 (8), 946-950 (2017).</li><li>. InVesalius Available from: <a target="_blank" href="https://www.cti.gov.br/en/invesalius">https://www.cti.gov.br/en/invesalius</a> (2018)</li><li>. Blender Available from: <a target="_blank" href="https://www.blender.org/">https://www.blender.org/</a> (2018)</li><li>. Free3D Available from: <a target="_blank" href="https://free3d.com/3d-models/human">https://free3d.com/3d-models/human</a> (2018)</li><li>. MakerBot Replicator+ Available from: <a target="_blank" href="https://www.makerbot.com/replicator/">https://www.makerbot.com/replicator/</a> (2018)</li><li>. Artec Eva Lite Available from: <a target="_blank" href="https://www.artec3d.com/portable-3d-scanners/artec-eva-lite">https://www.artec3d.com/portable-3d-scanners/artec-eva-lite</a> (2018)</li><li>Guerrero-de-Mier, A., Espinosa, M. 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CAD/CAM reconstruction is considered to contribute to the attainment of an accurate osteotomy length, width, and angle in cutting bones while using cutting guides4,5,6,7,8,9,10,11,12,13<s...

The use of CAD/CAM techniques has recently increased in dental and denture work. Following this evolution of CAD/CAM, osteocutaneous flap transfers using CAD/CAM are now used in the field of mandibular reconstruction after an oncologic wide resection of malignant tumors1,2,3. Several companies in Western countries have begun to supply and sell a CAD/CAM cutting guide for the mandible region. A CAD/CAM reconstruction of the mandible is considered to have an advantage in terms of accuracy4,5,6,7,8,9,10,11. However, a disadvantage is that this technique is available in limited areas worldwide and it is very expensive12. Thus, CAD/CAM reconstruction for maxillary lesions has not yet become popular. The number of the cases of maxillary reconstruction is lower than that for the mandible, and commercial guides are not common.
Because commercial maxillary CAD/CAM guides are not sold in Japan, we have developed CAD/CAM surgical guides using an in-house approach. The clinical effectiveness of the CAD/CAM guides has already been reported13,14,15,16,17,18,19, but there is no report of how to design them. The purpose of the present report is to show the CAD/CAM design method using a low-cost in-house approach.

<table border="0" cellpadding="0" cellspacing="0" style="width:1292px;" width="1291">
	<tbody>
		<tr height="66">
			<td height="66" style="height:66px;width:523px;">Information Technology Center, Renato Archer, Campinas, Brazil</td>
			<td style="width:316px;">InVesalius</td>
			<td style="width:383px;">Free software https://www.cti.gov.br/en/invesalius</td>
			<td style="width:71px;"></td>
		</tr>
		<tr height="66">
			<td height="66" style="height:66px;">The Blender Foundation, Amsterdam, Netherlands</td>
			<td>Blender</td>
			<td style="width:383px;">Free software https://www.blender.org/</td>
			<td></td>
		</tr>
		<tr height="66">
			<td height="66" style="height:66px;">TurboSquid, Inc. 935 Gravier St., Suite 1600, New Orleans, LA.</td>
			<td>Free 3D skeletal data file</td>
			<td style="width:383px;">Free3D https://free3d.com/3d-models/human</td>
			<td></td>
		</tr>
		<tr height="66">
			<td height="66" style="height:66px;">MakerBot Industries, LLC One MetroTech Center, 21st Fl, Brooklyn, NY.</td>
			<td>MakerBot Replicator+</td>
			<td>https://www.makerbot.com/replicator/</td>
			<td></td>
		</tr>
		<tr height="66">
			<td height="66" style="height:66px;width:523px;">YouTube (Google, Inc.), 901 Cherry Ave. San Bruno, CA</td>
			<td>video sharing website.</td>
			<td>https://www.youtube.com/results?search_query=invesalius+dicom+to+stl</td>
			<td></td>
		</tr>
		<tr height="66">
			<td height="66" style="height:66px;">Artec 3D, 2, rue Jean Engling, Luxembourg</td>
			<td>Artec Eva Lite</td>
			<td>https://www.artec3d.com/portable-3d-scanners/artec-eva-lite</td>
			<td></td>
		</tr>
		<tr height="66">
			<td height="66" style="height:66px;">CloudCompare</td>
			<td>CloudCompare</td>
			<td>http://www.danielgm.net/cc/</td>
			<td></td>
		</tr>
	</tbody>
</table>

designing cad/cam surgical guides for maxillary reconstruction using an in-house approach

Computer-aided design/computer-assisted manufacturing (CAD/CAM) is now being evaluated as a preparative technique for maxillofacial surgery. Because this technique is expensive and available in only limited areas of the world, we developed a novel CAD/CAM surgical guide using an in-house approach. By using the CAD software, the maxillary resection area and cutting planes and the fibular cutting planes and angles are determined. Once the resection area is decided, the necessary faces are extracted using a Boolean modifier. These superficial faces are united to fit the surface of the bones and thickened to stabilize the solids. Not only the cutting guides for the fibula and maxilla but also the location arrangement of the transferred bone segments is defined by thickening the superficial faces. The CAD design is recorded as .stl files and three-dimensionally (3-D) printed as actual surgical guides. To check the accuracy of the guides, model surgery using 3-D-printed facial and fibular models is performed. These methods may be used to assist surgeons where commercial guides are not available.

Using the procedure presented here, the resection area was determined first. Using CAD software, the resection area was completely circumscribed by the faces. This area was subtracted from the facial bone by a Boolean operation. The fibula image was placed on the defect, and fibular cutting faces were placed in the appropriate reconstructed points. All fibular cutting faces were linked to the fibula in a parent setting. These faces were made smaller and were united to make solids. The fib...

Watch this Scientific Journal Video about Designing CAD/CAM Surgical Guides for Maxillary Reconstruction Using an In-house Approach at JoVE.com

Designing CAD/CAM Surgical Guides for Maxillary Reconstruction Using an In-house Approach

Methods for designing a computer-aided design/computer-aided manufacturing (CAD/CAM) surgical guide are shown. Cutting planes are separated, united, and thickened to easily visualize the necessary bone transfer. These designs can be three-dimensional printed and checked for accuracy.

Computer-aided design/computer-assisted manufacturing (CAD/CAM) is now being evaluated as a preparative technique for maxillofacial surgery. Because this ...

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