This method can help answer a few questions in the method of malignancy field about characterization of a cell that initiate a malignancy. The main advantage of this technique is that it provides a foundation for the functional analysis of these c
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We describe the use of hematopoietic stem cell transplantation (HSCT) to assess the malignant potential of genetically engineered hematopoietic cells. HSCT is useful for evaluating various malignant hematopoietic cells in vivo as well as generating a large cohort of mice with myelodysplastic syndromes (MDS) or leukemia to evaluate novel therapies.