Live Cell Imaging of Dynamic Adhesion and Evaluation
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Results: Representative Human PBMC Adherence Assessment
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Conclusion
Transcript
This method can help answering key questions of basic immunobiology and inflammatory bowel disease research regarding the adhesion cascade of immune cells required for homing to peripheral organs. The main advantage of this technique is that it is
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Dynamic adhesion of immune cells to the vessel wall is a prerequisite for gut homing. Here, we present a protocol for a functional in vitro assay for the impact analysis of anti-integrin antibodies, chemokines or other factors on the dynamic cell adhesion of human cells using addressin-coated capillaries.