HIV Infection Analysis and Viral Suppression and Rebound Validation
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Results: Engraftment Validation and HIV Infection and Suppression Analyses
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Conclusion
Transcript
These matters can help answer key questions in HIV/AIDS research, such as the molecular mechanism and the prognosis of HIV infection, and how and where the latency reservoir is established. The advantage of this technique is that it is non-invasiv
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This protocol provides a method to establish humanized mice (hu-NSG) via intrahepatic injection of human hematopoietic stem cells into radiation-conditioned neonatal NSG mice. The hu-NSG mouse is susceptible to HIV infection and combinatorial antiretroviral therapy (cART) and serves as a suitable pathophysiological model for HIV replication and latency investigations.