Name: evaluating targeting accuracy in the focal plane for an ultrasound-guided high-intensity focused ultrasound phased-array system
Uploaded: 2019-03-06T14:45:00
Description: Watch this Scientific Journal Video about Evaluating Targeting Accuracy in the Focal Plane for an Ultrasound-guided High-intensity Focused Ultrasound Phased-array System at JoVE.com

这项工作得到了国家自然科学基金 (81402522)、上海市科技委员会 (17441907400)、上海交通大学上海关键技术研发项目 (17441907400) 和上海交通大学的部分支持。医疗工程研究基金 (yg2017qn40, YG2017QN40)。中汇医疗科技 (上海) 有限公司也因提供 usghifu 系统而被公认。作者感谢朱文珍和董俊辉对实验的准备和帮助。

1. 标记设计和制造
<ol><li>使用计算机辅助设计软件设计正方形模型。将每一侧设置为长度为40毫米、厚度为2毫米的木棍, 在正方形模型的每个角放置直径为10毫米的实心球。</li>
	<li>以丙烯腈丁苯苯乙烯光敏树脂为原料进行印刷。</li>
	<li>将3d 模型文件发送给制造商进行制造。</li>
</ol>2. 幻影准备
<ol><li>用硅胶将塑料圆筒 (直径为8厘米, 高度为3厘米) 连接到丙烯酸底板上, 使其在?...

<ol>
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机器人部件已被用于体外 usghifu 系统。为了评估这些系统的靶向精度,单独或联合使用了参考标记11、12、18、体外组织17、肿瘤模拟模型和温度敏感幻影10,20。与这些研究中的协议相比, 这种方法在临床上的相关性更高, 便于量化焦平面上的目标误差。通过将参考标记?...

相控阵越来越多地在 hifu 系统中设计和装备1、2、3、4、5、6、7。在 usghifu 相控阵系统中, 美国成像探头通常安装在球面 hifu 传感器1,2,8的中心孔中。该探头可在三维空间9中旋转, 用于目标定位和图像重建。对于 hifu 治疗的安全性和有效性, 需要精确的定位。然而, 大多数评估目标精度的研究都是为磁共振导向的 hifu 系统或配置了自聚焦 hifu 传感器10,11的usghifu 系统进行的,12,13,14,15,16. 下文所述方法的目的是评价 usghfu 相控阵系统在焦平面上的瞄准精度。
在评价临床 usghfu 相控阵系统的靶向精度时, 采用了沿临床相关光束路径的牛马氏标记嵌入幻影。一个在角落有四个球的正方形模型被制造出来, 并与牛肌肉结合, 嵌入到透明的幻影中。根据在处理平面上重建的美国图像中识别的四个球的中心位置, 选择一个规则六边形作为目标。hifu 超声后, 对幻影的治疗平面进行扫描, 并在扫描图像中确定病变的边界以及四个球的位置。通过测量目标中心和病变中心之间的距离, 以及三个导数参数, 可以评估目标精度。
与基于单焦点的方法相比, 该方法比使用机器人运动与特定参考对象11、17、18 进行定位误差的测量更简单, 在临床上更相关点消融在一个均匀的幻影10。该方法可用于评价 usghifu 相控阵系统的瞄准精度。它还可用于其他配备自聚焦 hifu 传感器的 usghifu 系统。

<table border="0" cellpadding="0" cellspacing="0" style="width:849px;" width="849">
	<colgroup>
		<col />
		<col />
		<col />
		<col />
	</colgroup>
	<tbody>
		<tr height="21">
			<td height="21" style="height:21px;width:233px;">Acrylamide</td>
			<td style="width:276px;">Amresco</td>
			<td style="width:160px;">D403-2</td>
			<td style="width:180px;"></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Acrylic baseboard</td>
			<td>LAO NIAO STORES</td>
			<td>customized</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Acrylic cylindrical water tank&#160;</td>
			<td>LAO NIAO STORES</td>
			<td>customized</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Ammonium persulfate</td>
			<td>Yatai United Chemical Co., Ltd (Wuxi, China)</td>
			<td>2017-03-01</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Beaker</td>
			<td>East China Chemical Reagent Instrument Store</td>
			<td></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Bis-acrylamide</td>
			<td>Amresco</td>
			<td>M0172</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Bovine muscle</td>
			<td>Market</td>
			<td style="width:160px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Chopping board</td>
			<td>JIACHI</td>
			<td dir="LTR">JC-ZB40</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Cylindrical plastic&#160;phantom holder</td>
			<td>QIYINPAI</td>
			<td>customized</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Degassed deionized water</td>
			<td style="width:276px;"></td>
			<td style="width:160px;"></td>
			<td>made by the USgHIFU system</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Electric balance</td>
			<td>YINGHENG</td>
			<td>11119453359</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Glass rod</td>
			<td>East China Chemical Reagent Instrument Store</td>
			<td></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Knife</td>
			<td>SHIBAZI</td>
			<td dir="LTR">SL1210-C</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Mask</td>
			<td>Medicom</td>
			<td>2498</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">N,N,N&#8217;,N&#8217;&#8211;Tetramethylethylenediamine</td>
			<td>Zhanyun Chemical Co., Ltd (Shanghai, China)</td>
			<td></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Rubber glove</td>
			<td>AMMEX</td>
			<td>YZB/MAL 0587-2018</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Scanner</td>
			<td>Fuji Xerox</td>
			<td>DocuPrint M268dw</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Screwdriver</td>
			<td>Stanley</td>
			<td>T6</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Silica gel</td>
			<td>GE</td>
			<td>381</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Square model</td>
			<td>QIYINPAI</td>
			<td>customized</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Stainless steel spoons</td>
			<td>East China Chemical Reagent Instrument Store</td>
			<td></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Sucker</td>
			<td>East China Chemical Reagent Instrument Store</td>
			<td></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Swine muscle</td>
			<td>Market</td>
			<td></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">USgHIFU system</td>
			<td>Zhonghui Medical Technology (Shanghai) Co., Ltd.</td>
			<td>SUA-I</td>
			<td></td>
		</tr>
	</tbody>
</table>

evaluating targeting accuracy in the focal plane for an ultrasound-guided high-intensity focused ultrasound phased-array system

在现有的体外超声引导的 hifu (usghifu) 系统中, 相控阵被越来越多地用作高强度聚焦超声 (hifu) 传感器。此类系统中的 hifu 传感器通常呈球形, 中央孔安装在美国成像探头上, 可以旋转。处理平面上的图像可以通过在探头旋转过程中获得的图像序列进行重建。因此, 可以在重建图像上制定处理方案。为了评价这种系统的焦平面上的瞄准精度, 描述了一种使用牛肌肉和标记嵌入幻影的方法的协议。在幻象中, 正方形树脂模型角部的四个实心球作为重建图像的参考标记。目标应移动, 以便其中心和正方形模型的中心能够根据其在重建图像中的相对位置重合。厚度约为30毫米的猪肌肉被放置在幻影上方, 以模拟临床环境中的光束路径。超声后, 扫描幻影中的治疗平面, 并从扫描图像中提取相关病变的边界。通过测量目标中心和病变中心之间的距离, 以及三个导数参数, 可以评估目标精度。该方法不仅可以评估由多个焦点组成的目标的瞄准精度, 而不是在 usghfu 相控阵系统的临床相关光束路径中的单个焦点, 而且还可用于临床前评估或定期维护配备相控阵或自聚焦 hifu 传感器的 usghifu 系统。

我们制作了幻象, 专门用于评估具有三种不同尺寸目标的临床 usghfu 相控阵系统的定位精度。图 1以0°和90°的角度显示美国图像。界面清晰, 正方形模型的木棍在美国图像中很明亮。图 2显示了在处理平面上重建的美国图像和最大目标的焦点。四个球的中心是由大小相同、灰度值最高的蓝色圆圈决定的。图 3...

Watch this Scientific Journal Video about Evaluating Targeting Accuracy in the Focal Plane for an Ultrasound-guided High-intensity Focused Ultrasound Phased-array System at JoVE.com

Evaluating Targeting Accuracy in the Focal Plane for an Ultrasound-guided High-intensity Focused Ultrasound Phased-array System

超声引导高强度聚焦超声相控阵系统焦平面定位精度的评价

本研究描述了一种评估超声引导高强度聚焦超声相控阵系统焦平面定位精度的方案。

Phased arrays are increasingly used as high-intensity focused ultrasound (HIFU) transducers in the existing extracorporeal ultrasound-guided HIFU ...

精确定位对于确保图像引导、高强度聚焦超声系统的安全性和有效性至关重要。我们的协议可以评估超声引导、高强度聚焦超声相位阵列系统的定位精度。该技术可用于评估治疗平面的靶向精度，同时考虑临床相关的组织路径。该方法可应用于超声波引导、高强度聚焦超声系统，采用不同超声图像重建方法进行自聚焦传感器。该方法的可视化演示可以帮助他人充分了解协议，特别是如何确定重建后的超声图像中目标的位置。在制作幻像之前，请制作模型。此 3D 打印模型是一个侧面长度为 40 毫米的正方形。每个角都有一个实心球。随着模型在手，使幻象架。为此，得到一个丙烯酸底板和一个八厘米直径的塑料缸，是三厘米高。使用硅胶将其连接以形成支架。让大会坐一个小时。现在，继续从新鲜的牛肌肉的幻影。将肌肉切成 30 毫米和 10 毫米厚度的正方形。用风扇将组织通风两小时，以蒸发水分。接下来，准备使用危险化学品。将去气和去维化的水倒入烧杯中。加入丙烯酰胺，搅拌至溶解。然后，加入双丙烯酰胺，搅拌至溶解。最后，加入四甲苯二胺，搅拌至溶液均匀。这是解决方案之一。在另一个烧杯中，用去气和去气化的水，加入硫酸铵，搅拌溶解。这是解决方案二。幻像凝固后，检索 3D 打印模型，并放在幻像表面上。模型到位后，下一步是将切片牛肌肉放在模型的中间。将溶液的其余部分倒入幻像支架中。移动牛肌肉以去除幻象和切片界面上的空气。继续将溶液的剩余两个倒入幻像支架中。然后，搅拌五秒钟。调整肌肉的位置，以在幻影的中心，让一切坐20分钟凝固。凝固后，用螺丝刀取出硅胶，将气缸和底座放在一起，然后慢慢分离两者。启动超声波引导、高强度聚焦超声系统。打开水处理模块，设置循环速度。要继续，在室温下，有一个装满脱气水的圆柱形水箱。罐体直径为30厘米，高度为13厘米。得到幻象架，并放在去气的水中。采取措施确保支架固定到位。接下来，移动治疗床和治疗单元，让成像幻影。治疗装置的气球应浸入脱气水中。在继续之前，先准备一份猪肌肉样本。样品长约100毫米，厚约30毫米。将样品放在一边，然后缓慢地上下移动治疗单元。目标是确保治疗平面位于切片牛肌肉和幻象的上部界面。使用超声波成像探头在零度时，移动水箱，使成像轴穿过图像中两条平行线的中间。接下来，将成像探头旋转到 90 度。然后，移动油箱，使轴穿过图像中两条平行线的中间。在几何聚焦深度重建处理平面的超声波图像。检查四个球是否清楚地显示在重建的图像中。此外，检查目标是否位于方形模型的中心。准备好后，抬起治疗单元，将猪肌肉放在幻象上方。在这里，猪的肌肉已经到位，并准备下一步。将治疗单元移回成像位置。将几何焦点的深度安排为牛肌上表面下方三毫米。继续设置高强度聚焦超声波声的参数，包括脉冲持续时间和功率等。设置所选六边形虚拟目标的曝光时间以及相位阵列几何中心焦点两秒的曝光时间。启动声波，并踩在声波仪器的脚踏板上。在声波化过程中，观察和记录超声波图像，以便比较不同样品的回声性。在使用类似准备的幻像与其他虚拟目标重复声波步骤之前，请删除幻像。这是一个零度角的超声波图像。90 度角的超声波图像与此类似。这两幅图像都显示了猪肌肉、幻影和牛肌肉之间的清晰界面。此外，方形模型的木棍是明亮的。这是处理平面中重建的图像。蓝色圆圈包含红色方块中最高的平均灰色值，并标识模型中四个球的位置。蓝色圆圈还确定方形模型的中心，即目标的中心。棕色方块表示最大常规六边形目标中的焦点。确定重建的超声波图像中四个球的位置对于将目标中心与模型中心进行匹配非常重要。用于幻象制备的化学材料具有轻微危险性。手术过程中应佩戴口罩和手套。

Research

JoVE Journal

Engineering

Evaluating Plasmonic Transport in Current-carrying Silver Nanowires

Plasmonics is an emerging technology capable of simultaneously transporting a plasmonic signal and an electronic signal on the same information ...

科研

工程学

Measuring Material Microstructure Under Flow Using 1-2 Plane Flow-Small Angle Neutron Scattering

测量材料在微流使用1-2面流小角中子散射

A new small-angle neutron scattering (SANS) sample environment optimized for studying the microstructure of complex fluids under simple shear flow is ...

Laboratory Drop Towers for the Experimental Simulation of Dust-aggregate Collisions in the Early Solar System

实验室落塔的粉尘聚集在碰撞早期太阳系的实验模拟

For the purpose of investigating the evolution of dust aggregates in the early Solar System, we developed two vacuum drop towers in which fragile dust ...

Ambient Method for the Production of an Ionically Gated Carbon Nanotube Common Cathode in Tandem Organic Solar Cells

对于一个以离子门控碳纳米管共阴极的串联有机太阳能电池的生产环境法

A method of fabricating organic photovoltaic (OPV) tandems that requires no vacuum processing is presented. These devices are comprised of two ...

Characterization of Full Set Material Constants and Their Temperature Dependence for Piezoelectric Materials Using Resonant Ultrasound Spectroscopy

全套材料常数表征及其温度依赖性的压电材料使用共振超声波谱

During the operation of high power electromechanical devices, a temperature rise is unavoidable due to mechanical and electrical losses, causing the ...

Focused Ion Beam Fabrication of LiPON-based Solid-state Lithium-ion Nanobatteries for In Situ Testing

Focused Ion Beam Fabrication of LiPON-based Solid-state Lithium-ion Nanobatteries for In Situ Testing

基于 LiPON 的固态锂离子 Nanobatteries 的聚焦离子束制备方法在原位测试中的研究

Solid-state electrolytes are a promising replacement for current organic liquid electrolytes, enabling higher energy densities and improved safety of ...

Controllable Nucleation of Cavitation from Plasmonic Gold Nanoparticles for Enhancing High Intensity Focused Ultrasound Applications

等离子金纳米粒子空化的可控核增强高强度聚焦超声应用

In this study, plasmonic gold nanoparticles were simultaneously exposed to pulsed near-infrared laser light and high intensity focused ultrasound (HIFU) ...

Multiplexing Focused Ultrasound Stimulation with Fluorescence Microscopy

荧光显微镜对聚焦超声的刺激

By focusing low-intensity ultrasound pulses that penetrate soft tissues, LIPUS represents a promising biomedical technology to remotely and safely ...

Evaluating Usability Aspects of a Mixed Reality Solution for Immersive Analytics in Industry 4.0 Scenarios

评估工业 4.0 方案中沉浸式分析的混合现实解决方案的可用性方面

In medicine or industry, the analysis of high-dimensional data sets is increasingly required. However, available technical solutions are often complex to ...

3D Printing - Evaluating Particle Emissions of a 3D Printing Pen

3D 打印 - 评估 3D 打印笔的粒子排放

Three-dimensional (3D) printing as a type of additive manufacturing shows continuing increase in application and consumer popularity. The fused filament ...