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Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

DOI :

10.3791/59174-v

May 29th, 2020

May 29th, 2020

2,692 Views

1Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, 2Department of Pediatrics and Pathology, Johns Hopkins University

We describe an in vivo immunization, translational hepatitis model in BALB/c mice that can be utilized to study the pathogenesis of drug-induced autoimmune hepatitis including sex differences seen in this disease. We will describe how this model demonstrates reproducible analyses using in vivo and in vitro experimental techniques.

Tags

Drug induced

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