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7.8K Views
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07:56 min
August 12th, 2019
DOI :
10.3791/60050-v
Chapters
0:04
Title
0:28
Synthesis of Aza-Michael Adduct 4: Tricarbonyl[(2-5-η)-6-((2-phenylethyl) Amino cyclohepta-2,4-dien-1-one]Iron
1:48
Synthesis of Tricarbonyl[(2-5-η)-6-(2-methylanilino)cyclohepta-2, 4-dien-1-one]Iron (3)
2:55
Protection of Amine 4 as a Tert-butyl Carbamate
4:30
Synthesis of Tert-butyl (6-oxocyclohepta-2, 4-dien-1-yl)(2-phenylethyl) Carbamate (6)
5:41
Results: Description of NMR Spectral Data for Selected Compounds
7:17
Conclusion
Transcript
该协议是合成氨化龙衍生物的一种有效方法。这些化合物可以作为合成中间体,用于合成结构复杂的胺。该技术的一个优点是,aza-Micheal 的添加可以在具有许多胺基材的无溶剂工艺中完成。
这简化了反应设置和产品隔离。加入PTFE磁搅拌棒,150毫克三碳基龙铁和0.154毫升苯乙胺到一个德拉姆小瓶。将小瓶盖在空气大气中,开始磁搅拌。
通过从反应混合物中去除少量等分,在脱化氯仿中溶解,并获取质子 NMR 光谱,定期监测反应。观察质子 NMR 光谱中三碳基龙铁信号的消失。消失
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Summary
详细介绍了在三碳基(特罗酮)铁中添加胺核亲子的代表性实验程序以及随后产生的复合物的脱金属化。
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