Induction of Leptin Receptor Long Isoform (LepRb) Expression
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Results: Representative Effects of Leptin and LepRb Expression on HVR
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Conclusion
Transcript
Our protocol can be used to examine the respiratory effects of leptin on the carotid body in the peripheral chemoreflex breathing control, and physiological responses to hypoxia. We can also assess the effects of loss and gain of carotid body func
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Our study focuses on the effects of leptin signaling in carotid body (CB) on the hypoxic ventilatory response (HVR). We performed 'loss of function' experiments measuring the effect of leptin on HVR after CB denervation and 'gain of function' experiments measuring HVR after overexpression of the leptin receptor in CB.