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DOI :
10.3791/60925-v
March 2nd, 2020
Chapters
0:05
Introduction
1:27
Seeding the "Brain Side" Channel and Differentiating EZ Spheres into Mixed Neural Cultures
3:04
Seeding iBMECs (iPSC-Derived Brain Microvascular Endothelial Cells) into the Bottom Channel to Generate the "Blood Side"
5:27
Initiation of Flow
8:12
Results: Immunocytochemistry and Permeability of the iPSC-Base Blood-Brain Barrier Chip
9:17
Conclusion
血脑屏障(BBB)是一种多细胞神经血管单元,严密调节大脑平衡。通过结合人类 iPSC 和芯片上器官技术,我们生成了个性化的 BBB 芯片,适用于疾病建模和 CNS 药物渗透性预测。介绍了BBB芯片的生成和运行的详细方案。
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