Preparation of Light Emitting Diode (LED) for Blue Light Illumination
2:13
Imaging of Zebrafish Larvae Expressing Optogenetic TAR DNA-binding Protein 43 (TDP-43)
3:58
Light Stimulation of Optogenetic TDP-43h-Expressing Fish by Field Illumination of a Blue LED Light
4:35
Results: Characterization of TDP-43 Phase Transition in Spinal Motor Neurons of Zebrafish Larvae
6:34
Conclusion
Transcript
Så denne protokol gør det muligt for os at fremkalde patologiske faseovergange af TDP-43 og løse deres cellulære konsekvens i spinalmotoren neuroner in vivo, hvilket er relevant for at forstå, hvorfor motoriske neuroner degenererer i ALS. På grund
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Vi beskriver en protokol til at fremkalde fase overgang af TAR DNA-bindende protein 43 (TDP-43) af lys i spinal motor neuroner ved hjælp af zebrafisk som model.