Mitochondrial Oxygen Consumption and Membrane Potential (ΔΨ)
5:25
Results: Determination of Voltage Threshold for mPTP Opening in Neonatal Fragile X Syndrome Mice
7:03
Conclusion
Transcript
This protocol provides a new way to investigate the low conductance opening of the mitochondrial permeability transition pore. The main advantage of this technique is that it provides an easy way to measure the open probability of the pore as a fu
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This method exploits the contribution of the mitochondrial permeability transition pore to low-conductance proton leak to determine the voltage threshold for pore opening in neonatal fragile X syndrome mice with increased cardiomyocyte mitochondrial coenzyme Q content compared to wildtype control.